CAS 1109283-93-3

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

CAS: 1109283-93-3

Formula: C₂₂H₂₃F₂N₇OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.5261

Ref: IN-DA0099CP

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxa mide

CAS: 1109283-93-3

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3)yl)thiophene-2 -carboxamide (NCCXVII) is a potent and selective inhibitor of the human Btk protein. The IC50 values for NCCXVII were determined to be 1.0 μM in a cell free assay and 10 nM in an intact cell assay. It has been shown that NCCXVII inhibits ligand binding to the Btk receptor with a Ki of 0.8 nM, suggesting that it is a competitive inhibitor of ATP binding to the kinase domain of Btk.

Formula: C₂₂H₂₃F₂N₇OS

Purity: Min. 95%

Molecular weight: 471.5 g/mol

Ref: 3D-JUB28393

MARK-IN-1

CAS: 1109283-93-3

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).

Formula: C₂₂H₂₃F₂N₇OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.53

Ref: TM-T11945