CAS 1109283-93-3

Formula: C22H23F2N7OS

InChI: InChI=1S/C22H23F2N7OS/c1-12-15(6-18(33-12)21(32)29-19-17(25)4-3-5-22(19,23)24)16-9-28-31-11-13(7-26-20(16)31)14-8-27-30(2)10-14/h6-11,17,19H,3-5,25H2,1-2H3,(H,29,32)/t17-,19-/m1/s1

InChI key: SFILVHFYISPBOI-IEBWSBKVSA-N

SMILES: CC1=C(C=C(S1)C(=O)N[C@@H]2[C@@H](CCCC2(F)F)N)C3=C4N=CC(=CN4N=C3)C5=CN(N=C5)C

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

CAS: 1109283-93-3

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

Formula: C₂₂H₂₃F₂N₇OS

Purity: 98%

Molecular weight: 471.53

Ref: 54-PC1028990

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

CAS: 1109283-93-3

Formula: C₂₂H₂₃F₂N₇OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.5261

Ref: IN-DA0099CP

MARK-IN-1

CAS: 1109283-93-3

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).

Formula: C₂₂H₂₃F₂N₇OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.53

Ref: TM-T11945

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxa mide

CAS: 1109283-93-3

N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3)yl)thiophene-2 -carboxamide (NCCXVII) is a potent and selective inhibitor of the human Btk protein. The IC50 values for NCCXVII were determined to be 1.0 μM in a cell free assay and 10 nM in an intact cell assay. It has been shown that NCCXVII inhibits ligand binding to the Btk receptor with a Ki of 0.8 nM, suggesting that it is a competitive inhibitor of ATP binding to the kinase domain of Btk.

Formula: C₂₂H₂₃F₂N₇OS

Purity: Min. 95%

Molecular weight: 471.5 g/mol

Ref: 3D-JUB28393