CAS 112093-28-4

Endoxifen

Description:

Endoxifen is a selective estrogen receptor modulator (SERM) primarily known for its role in breast cancer treatment, particularly in patients with estrogen receptor-positive tumors. It is an active metabolite of tamoxifen, which is commonly used in hormone therapy for breast cancer. Endoxifen exhibits both estrogenic and anti-estrogenic properties, depending on the tissue type, which allows it to inhibit the growth of estrogen-dependent tumors while potentially preserving beneficial estrogenic effects in other tissues. The substance is characterized by its ability to bind to estrogen receptors, modulating gene expression and cellular proliferation. Its pharmacokinetics include oral bioavailability and a relatively long half-life, making it effective in therapeutic regimens. Additionally, endoxifen has been studied for its potential in overcoming resistance to other anti-estrogen therapies. As with many SERMs, the side effects may include hot flashes, risk of thromboembolic events, and other estrogen-related effects, necessitating careful monitoring during treatment.

Formula: C₂₅H₂₇NO₂

InChI: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24-

InChI key: InChIKey=MHJBZVSGOZTKRH-IZHYLOQSSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCNC)C=C2)/C3=CC=C(O)C=C3

Synonyms:

• (Z)-4-Hydroxy-N-desmethyl Tamoxifen
• (Z)-Endoxifen
• 4-Hydroxy-N-desmethyltamoxifen
• 4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
• 4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
• N-Desmethyl-4-hydroxytamoxifen
• Phenol, 4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
• Phenol, 4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-
• Phenol, 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-

Endoxifen (Z-isomer)

CAS: 112093-28-4

Endoxifen (Z-isomer)

Formula: C₂₅H₂₇NO₂

Purity: ≥98%

Molecular weight: 373.49

Ref: 54-BUP01975

Endoxifen (Z-isomer)

CAS: 112093-28-4

Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.

Formula: C₂₅H₂₇NO₂

Purity: 99.19% - 99.81%

Color and Shape: White Solid

Molecular weight: 373.49

Ref: TM-T2280

Endoxifen

CAS: 112093-28-4

Formula: C₂₅H₂₇NO₂

Molecular weight: 373.50

Ref: 4Z-E-249001

Endoxifen (Z-isomer)

CAS: 112093-28-4

Ref: BE-RMCT016035

(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)

Controlled Product

CAS: 112093-28-4

Stability Light Sensitive, Temperature Sensitive
Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

Formula: C₂₅H₂₇NO₂

Color and Shape: Neat

Molecular weight: 373.49

Ref: TR-H938500

Z-Endoxifen

CAS: 112093-28-4

Z-Endoxifen is the active metabolite of tamoxifen (FT32122, BT164438, FT27994) that acts as an inhibitor of the enzyme aromatase and as inhibitor of the binding of estradiol to estrogen receptors. As an antitumour agent, Z-endoxifen has shown that it has the potential to treat endocrine-resistant estrogen receptor-positive (ER+) breast cancers. Endoxifen is the most effective non-competitive inhibitor of aromatase by conferring molecular rigidity upon binding.

Formula: C₂₅H₂₇NO₂

Purity: Min. 95%

Molecular weight: 373.49 g/mol

Ref: 3D-BE172975

(Z)-4-Hydroxy-N-Desmethyl Tamoxifen

CAS: 112093-28-4

Formula: C₂₅H₂₇NO₂

Molecular weight: 373.5

Ref: ST-EA-CP-T40013