CAS 112648-68-7: U-73122

Description: U-73122 is a chemical compound known for its role as a selective inhibitor of phospholipase C (PLC), an enzyme involved in various cellular signaling pathways. It is often utilized in biochemical research to study signal transduction mechanisms, particularly those related to G-protein-coupled receptors. U-73122 is characterized by its ability to disrupt the hydrolysis of phosphatidylinositol 4,5-bisphosphate, leading to a decrease in inositol trisphosphate and diacylglycerol levels, which are crucial for calcium signaling and protein kinase activation. The compound is typically used in laboratory settings and is not intended for therapeutic use in humans. Its chemical structure includes specific functional groups that contribute to its inhibitory activity, making it a valuable tool for researchers investigating the roles of PLC in various physiological and pathological processes. As with many research chemicals, proper handling and safety precautions are essential due to its potential biological effects.

Formula: C₂₉H₄₀N₂O₃

InChI: InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1

InChI key: InChIKey=LUFAORPFSVMJIW-ZRJUGLEFSA-N

SMILES: O=C1C=CC(=O)N1CCCCCCNC2CCC3C4CCC5=CC(OC)=CC=C5C4CCC23C

Synonyms:

• 1-(6-{[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl)-1H-pyrrole-2,5-dione
• 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
• 1H-Pyrrole-2,5-dione, 1-[6-[[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-
• Estrane, 1H-pyrrole-2,5-dione deriv.
• U73122

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

CAS: 112648-68-7

• Formula: C₂₉H₄₀N₂O₃
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 464.6395

U-73122

CAS: 112648-68-7

• Purity: 97.98%
• Molecular weight: 464.64g/mol

U-73122 hydrate

CAS: 112648-68-7

• Formula: C₂₉H₄₀N₂O₃
• Molecular weight: 464.65

U-73122

CAS: 112648-68-7

U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.

• Formula: C₂₉H₄₀N₂O₃
• Purity: 97.50%
• Color and Shape: Solid Off-White
• Molecular weight: 464.64

U-73122

CAS: 112648-68-7

Inhibitor of aminosteroid phospholipase C

• Formula: C₂₉H₄₀N₂O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 464.64 g/mol