CAS 112901-68-5
:Amifostine trihydrate
Description:
Amifostine trihydrate, with the CAS number 112901-68-5, is a chemical compound primarily used as a cytoprotective agent in oncology. It is a prodrug that is converted in the body to its active form, which acts as a free radical scavenger, thereby protecting normal tissues from the harmful effects of chemotherapy and radiation therapy. The trihydrate form indicates that the compound contains three molecules of water, which can influence its solubility and stability. Amifostine is known for its ability to reduce the incidence of xerostomia (dry mouth) in patients undergoing head and neck radiation therapy. It is typically administered intravenously and has a relatively short half-life, necessitating careful timing in relation to chemotherapy or radiation treatments. The compound is characterized by its ability to donate thiol groups, which play a crucial role in its protective mechanisms. While generally well-tolerated, it can cause side effects such as hypotension and nausea, highlighting the importance of monitoring during administration.
Formula:C5H15N2O3PS
InChI:InChI=1/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
SMILES:C(CN)CNCCSP(=O)(O)O.O.O.O
Synonyms:- S-[2-(3-Aminopropyl)amino]ethyl]dihydrogen phosphorothioate,trihydrate
- 2-(3-Aminopropylamino)ethylsulfanylphosphonic acid trihydrate
- S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen phosphorothioate
- Anifostine trihydrate
- AMIFOSTIN
- AMINOPROPYL AMINOETHYLTHIOPHOSPHATE
- WR2721
- phosphorothioic acid s-(2-((3-aminopropyl)amino)ethyl) ester
- ethiofos
- S-2-(3-AMINOPROPYLAMINO)ETHYL O,O-DIHYDROGEN PHOSPHOROTHIOATE
- 2-[3-AMINOPROPYL]AMINOETHYL PHOSPHOROTHIOATE
- Amifostine
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 9 products.
Amifostine
CAS:Organo-sulfur compounds, nesoiFormula:C5H15N2O3PS·3H2OColor and Shape:White PowderMolecular weight:214.0541Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester),trihydrate
CAS:Formula:C5H21N2O6PSPurity:97%Color and Shape:SolidMolecular weight:268.2688S-(2-((3-Aminopropyl)Amino)Ethyl)O,O-DihydrogenPhosphorothioateTrihydrate
CAS:S-(2-((3-Aminopropyl)Amino)Ethyl)O,O-DihydrogenPhosphorothioateTrihydratePurity:97%Molecular weight:268.27g/molAmifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27Amifostine trihydrate
CAS:Purity:97.0%Color and Shape:Liquid, No data available.Molecular weight:268.260009765625Amifostine Trihydrate
CAS:Controlled Product<p>Applications Amifostine Trihydrate is a widely used cytoprotective and radio-protective agent.<br>References Adibhatla K.S., et al. Novel method of manufacture of high purity Amifostine trihydrate. Indian Pat. Appl. IN 2005CH01592 A 20080125. Jan 25, 2008<br></p>Formula:C5H15N2O3PS·3H2OColor and Shape:NeatMolecular weight:268.27Amifostine trihydrate
CAS:Amifostine trihydrate is a cytoprotective agent, which is a synthetic organic compound used primarily in oncology. It is a phosphorylated aminothiol prodrug derived from chemical synthesis. Its mode of action involves dephosphorylation to its active metabolite, WR-1065, by alkaline phosphatase enzymes present in normal tissues. This active form then scavenges free radicals and enhances DNA repair mechanisms, providing selective protection to normal tissues during chemotherapy or radiation therapy.Formula:C5H15N2O3PS·3H2OPurity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:268.27 g/mol
![Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester),trihydrate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00HCG5.jpg&w=3840&q=75)
