CAS 1129403-56-0

BBI-503(BB-503)

CAS: 1129403-56-0

Formula: C₃₁H₃₃N₅O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 539.6910

Ref: IN-DA008TOW

Amcasertib

CAS: 1129403-56-0

Amcasertib

Purity: ≥95%

Molecular weight: 539.69g/mol

Ref: 54-BUP12916

Amcasertib

CAS: 1129403-56-0

Amcasertib (BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways via targeting stemness kinases.

Formula: C₃₁H₃₃N₅O₂S

Purity: 97.56% - >99.99%

Color and Shape: Solid

Molecular weight: 539.69

Ref: TM-T3995

Amcasertib

Controlled Product

CAS: 1129403-56-0

Formula: C₃₁H₃₃N₅O₂S

Color and Shape: Neat

Molecular weight: 539.691

Ref: TR-A634611

Amcasertib (BBI503)

CAS: 1129403-56-0

Amcasertib is a β-catenin inhibitor that inhibits tumor growth and metastasis. It is currently in clinical trials for the treatment of cancer. Amcasertib inhibits the phosphorylation of β-catenin by GSK3β, which leads to its degradation by proteasomes, thereby reducing cellular levels of β-catenin. Amcasertib has also been shown to enhance the cytotoxicity of folfirinox, an anticancer drug. Amcasertib has a hydroxyl group at C-2 and a carbonyl group at C-4, which are necessary for binding to β-catenin. The lack of a disulfide bond makes amcasertib more stable than other potential β-catenin inhibitors.

Formula: C₃₁H₃₃N₅O₂S

Purity: Min. 95%

Molecular weight: 539.69 g/mol

Ref: 3D-EVB40356