CAS 1131-01-7

2-Chloro-N-(2,6-dimethylphenyl)acetamide

Description:

2-Chloro-N-(2,6-dimethylphenyl)acetamide, with the CAS number 1131-01-7, is an organic compound characterized by its amide functional group and the presence of a chlorine atom. This compound features a chloro substituent on the second carbon of the acetamide structure, which influences its reactivity and solubility. The presence of the 2,6-dimethylphenyl group contributes to its hydrophobic characteristics, making it less soluble in water but more soluble in organic solvents. The compound is typically a solid at room temperature and may exhibit moderate stability under standard conditions. Its chemical properties include potential reactivity with nucleophiles due to the electrophilic nature of the carbonyl carbon in the amide group. Additionally, the chlorine atom can participate in various substitution reactions, making this compound of interest in synthetic organic chemistry. Safety data should be consulted, as it may pose health risks if handled improperly, and appropriate safety measures should be taken during its use in laboratory settings.

Formula: C₁₀H₁₂ClNO

InChI: InChI=1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)

InChI key: InChIKey=FPQQSNUTBWFFLB-UHFFFAOYSA-N

SMILES: N(C(CCl)=O)C1=C(C)C=CC=C1C

Synonyms:

• 1-Chloroacetylamino-2,6-dimethylbenzene
• 2-Chloro-2',6'-acetoxylidide
• 2-Chloro-2,6-acetoxylidide
• 2-Chloro-2,6-dimethylacetanilide
• 2-Chloroaceto-2,6-xylidide
• 2′,6′-Acetoxylidide, 2-chloro-
• 2′,6′-Dimethyl-2-chloroacetanilide
• Acetamide, 2-chloro-N-(2,6-dimethylphenyl)-
• Chloroacetamido-2,6-xylidine
• Chloroaceto-2,6-xylidide
• N-(2,6-Dimethylphenyl)-2-chloroacetamide
• N-(2,6-Dimethylphenyl)-2-chloroethanamide
• N-(2,6-Dimethylphenyl)chloroacetamide
• N-(2,6-Xylyl)chloroacetamide
• N-(Chloroacetyl)-2,6-diethylaniline
• N-Chloroacetyl-2,6-dimethylaniline
• NSC 37260
• alpha-Chloro-2,6-dimethylacetanilide

2-Chloro-2',6'-dimethylacetanilide

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Purity: >98.0%(GC)(N)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 197.66

Ref: 3B-C2307

2-Chloro-2',6'-dimethylacetanilide, 99%

CAS: 1131-01-7

2-Chloro-2',6'-dimethylacetanilide is used in the determination of the enantiomers of tocainide in blood plasma by gas-liquid chromatography with electron-capture detection. It is a nonsteroidal antinflammatory drug. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesa

Formula: C₁₀H₁₂ClNO

Purity: 99%

Color and Shape: Crystals or powder or crystalline powder, White to pale brown or purple/grey

Molecular weight: 197.66

Ref: 02-L02727

Lidocaine Related Compound H

CAS: 1131-01-7

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof, nesoi

Formula: C₁₀H₁₂ClNO

Color and Shape: White Off-White Powder

Molecular weight: 197.06074

Ref: 45-1366080

Lidocaine EP Impurity H (Lidocaine USP Related Compound H)

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Color and Shape: White To Off-White Solid

Molecular weight: 197.66

Ref: 4Z-L-0618

2-Chloro-N-(2,6-dimethylphenyl)acetamide

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 197.6614

Ref: IN-DA00339G

2-Chloro-N-(2,6-dimethylphenyl)acetamide

Controlled Product

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Color and Shape: Neat

Molecular weight: 197.66

Ref: 86-MM0102.03

2-Chloro-2,6-dimethylacetanilide

CAS: 1131-01-7

Impurity Lidocaine EP Impurity H
Applications Lidocaine intermediate.
References Moen, A., et al.: Biocatal. Biotransform., 23, 45 (2005), Yogeeswari, P., et al.: Bioorg. Med. Chem. Lett., 17, 3712 (2007),

Formula: C₁₀H₁₂ClNO

Color and Shape: Neat

Molecular weight: 197.66

Ref: TR-C365375

2-chloro-N-(2,6-dimethylphenyl)acetamide

CAS: 1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

Formula: C₁₀H₁₂ClNO

Purity: >98%

Color and Shape: Solid

Molecular weight: 197.66138

Ref: 54-OR29215

Lidocaine EP Impurity H

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Molecular weight: 197.66

Ref: ST-EA-CP-L20008

2-Chloro-N-(2,6-dimethylphenyl)acetamide

CAS: 1131-01-7

Formula: C₁₀H₁₂ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 197.66

Ref: 10-F068295

N-(2,6-Dimethylphenyl)chloroacetamide

CAS: 1131-01-7

N-(2,6-Dimethylphenyl)chloroacetamide

Formula: C₁₀H₁₂ClNO

Purity: 98%

Molecular weight: 197.66

Ref: IN-DG17597

2-Chloro-2',6'-dimethyl-d6-acetanilide

Controlled Product

CAS: 1131-01-7

Stability Light Sensitive
Applications 2-Chloro-2',6'-dimethyl-d6-acetanilide is the labeled analogue of 2-Chloro-2',6'-dimethylacetanilide (C365375), an intermediate of Lidocaine (L397800), a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
References Moen, A., et al.: Biocatal. Biotransform., 23, 45 (2005); Yogeeswari, P., et al.: Bioorg. Med. Chem. Lett., 17, 3712 (2007); Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971); Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973); Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985); Davies, P.S., et al.: Drugs, 64, 937 (2004)

Formula: C₁₀H₆D₆ClNO

Color and Shape: Neat

Molecular weight: 203.7

Ref: TR-C365377

2-Chloro-N-(2,6-dimethylphenyl)acetamide

CAS: 1131-01-7

2-Chloro-N-(2,6-dimethylphenyl)acetamide is a compound identified as a cyclooxygenase (COX) inhibitor through predictions based on molecular topology.

Formula: C₁₀H₁₂ClNO

Molecular weight: 197.661

Ref: TM-T215062