CAS 1134-47-0
:Baclofen
Description:
Baclofen is a pharmaceutical compound primarily used as a muscle relaxant and antispastic agent. It is classified as a gamma-aminobutyric acid (GABA) derivative, functioning as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity. This mechanism makes it effective in treating conditions such as multiple sclerosis and spinal cord injuries, where muscle spasticity is prevalent. Baclofen is typically administered orally or via intrathecal delivery for severe cases. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can influence its bioavailability. Its molecular formula is C10H12ClNO2, and it has a moderate molecular weight. Baclofen's pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Side effects may include drowsiness, dizziness, and potential withdrawal symptoms if discontinued abruptly. Overall, Baclofen is a vital medication in managing spasticity, with a well-established profile in clinical use.
Formula:C10H12ClNO2
InChI:InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key:InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES:C(CC(O)=O)(CN)C1=CC=C(Cl)C=C1
Synonyms:- (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- (3S)-4-amino-3-(4-chlorophenyl)butanoic acid
- 4-Amino-3-(4-Chlorophenyl)Butanoic Acid
- 4-Amino-3-(4-Chlorophenyl)Butyric Acid
- 4-Amino-3-(p-chlorophenyl)butyric acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-4-Amino-3-p-chlorophenylbutanoic acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Baclofen
- Atrofen
- Ba 34647
- Baclofene
- Baclofeno
- Baclon
- Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
- Beta-(4-Chlorophenyl)-Gamma-Aminobutyric Acid
- Beta-(4-Chlorophenyl)Gaba
- Beta-(Aminomethyl)-4-Chlorobenzenepropanoic Acid
- Beta-(Aminomethyl)-P-Chlorohydrocinnamic Acid
- C 34647Ba
- CIBA Ba 34647
- Ciba 34,647-Ba
- DL-4-Amino-3-p-chlorophenylbutanoic acid
- Gamma-Amino-Beta-(P-Chlorophenyl)Butyric Acid
- Hydrocinnamic acid, β-(aminomethyl)-p-chloro-
- Lioresal
- dl-Baclofen
- β-(4-Chlorophenyl)-γ-aminobutyric acid
- β-(Aminomethyl)-4-chlorobenzenepropanoic acid
- β-(Aminomethyl)-p-chlorohydrocinnamic acid
- β-(p-Chlorophenyl)-γ-aminobutyric acid
- See more synonyms
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Baclofen
CAS:Controlled ProductGABA(B) agonist; anti-spastic agent; skeletal muscle relaxantFormula:C10H12ClNO2Purity:Min. 95%Color and Shape:PowderMolecular weight:213.66 g/molBaclofen - Bio-X ™
CAS:Controlled ProductBaclofen is a GABA-ergic agonist drug that is used to manage severe spasticity of the cerebral and spinal origin in patients. The exact action of this drug is unclear however it is said that Baclofen inhibits the transmission of both mono- and polysynaptic reflexes at the spinal cord, relaxing spasticity.
Formula:C10H12ClNO2Purity:Min. 95%Color and Shape:PowderMolecular weight:213.66 g/molBaclofen in Methanol:1mol/LNaOH=9:1
CAS:Methanol:1mol/LNaOH=9:1Formula:C10H12ClNO2Color and Shape:SolidMolecular weight:213.66(+/-)-Baclofen
CAS:M01382 - (+/-)-Baclofen
Formula:C10H12ClNO2Purity:98%Color and Shape:SolidMolecular weight:213.66Dibaclofen Urea Dicyclohexylammonium Salt
CAS:Controlled ProductApplications Dibaclofen Urea Dicyclohexylammonium Salt, is an impurity of Baclofen (B108000), which is an specific GABA-B receptor agonist, and muscle relaxant (skeletal). It is primarily used to treat spasticity.
References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)Formula:C21H20Cl2N2O5·2C12H24NColor and Shape:NeatMolecular weight:815.951Baclofen-d4,15N
CAS:Controlled ProductFormula:C10H8D4ClNO2Color and Shape:NeatMolecular weight:382.454
