CAS 1134-47-0

Baclofen

Description:

Baclofen is a pharmaceutical compound primarily used as a muscle relaxant and antispastic agent. It is classified as a gamma-aminobutyric acid (GABA) derivative, functioning as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity. This mechanism makes it effective in treating conditions such as multiple sclerosis and spinal cord injuries, where muscle spasticity is prevalent. Baclofen is typically administered orally or via intrathecal delivery for severe cases. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can influence its bioavailability. Its molecular formula is C10H12ClNO2, and it has a moderate molecular weight. Baclofen's pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Side effects may include drowsiness, dizziness, and potential withdrawal symptoms if discontinued abruptly. Overall, Baclofen is a vital medication in managing spasticity, with a well-established profile in clinical use.

Formula: C₁₀H₁₂ClNO₂

InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

InChI key: InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N

SMILES: C(CC(O)=O)(CN)C1=CC=C(Cl)C=C1

Synonyms:

• (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• (3S)-4-amino-3-(4-chlorophenyl)butanoic acid
• 4-Amino-3-(4-Chlorophenyl)Butanoic Acid
• 4-Amino-3-(4-Chlorophenyl)Butyric Acid
• 4-Amino-3-(p-chlorophenyl)butyric acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-4-Amino-3-p-chlorophenylbutanoic acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Baclofen
• Atrofen
• Ba 34647
• Baclofene
• Baclofeno
• Baclon
• Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
• Beta-(4-Chlorophenyl)-Gamma-Aminobutyric Acid
• Beta-(4-Chlorophenyl)Gaba
• Beta-(Aminomethyl)-4-Chlorobenzenepropanoic Acid
• Beta-(Aminomethyl)-P-Chlorohydrocinnamic Acid
• C 34647Ba
• CIBA Ba 34647
• Ciba 34,647-Ba
• DL-4-Amino-3-p-chlorophenylbutanoic acid
• Gamma-Amino-Beta-(P-Chlorophenyl)Butyric Acid
• Hydrocinnamic acid, β-(aminomethyl)-p-chloro-
• Lioresal
• dl-Baclofen
• β-(4-Chlorophenyl)-γ-aminobutyric acid
• β-(Aminomethyl)-4-chlorobenzenepropanoic acid
• β-(Aminomethyl)-p-chlorohydrocinnamic acid
• β-(p-Chlorophenyl)-γ-aminobutyric acid

Baclofen - Bio-X ™

Controlled Product

CAS: 1134-47-0

Baclofen is a GABA-ergic agonist drug that is used to manage severe spasticity of the cerebral and spinal origin in patients. The exact action of this drug is unclear however it is said that Baclofen inhibits the transmission of both mono- and polysynaptic reflexes at the spinal cord, relaxing spasticity.

Formula: C₁₀H₁₂ClNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 213.66 g/mol

Ref: 3D-BB166152

Baclofen

Controlled Product

CAS: 1134-47-0

GABA(B) agonist; anti-spastic agent; skeletal muscle relaxant

Formula: C₁₀H₁₂ClNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 213.66 g/mol

Ref: 3D-FB18127

(+/-)-Baclofen

CAS: 1134-47-0

M01382 - (+/-)-Baclofen

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.66

Ref: 10-M01382

Baclofen-d4,15N

Controlled Product

CAS: 1134-47-0

Formula: C₁₀H₈D₄ClNO₂

Color and Shape: Neat

Molecular weight: 382.454

Ref: TR-B108001