CAS 1134-47-0
:Baclofen
Description:
Baclofen is a pharmaceutical compound primarily used as a muscle relaxant and antispastic agent. It is classified as a gamma-aminobutyric acid (GABA) derivative, functioning as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity. This mechanism makes it effective in treating conditions such as multiple sclerosis and spinal cord injuries, where muscle spasticity is prevalent. Baclofen is typically administered orally or via intrathecal delivery for severe cases. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can influence its bioavailability. Its molecular formula is C10H12ClNO2, and it has a moderate molecular weight. Baclofen's pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Side effects may include drowsiness, dizziness, and potential withdrawal symptoms if discontinued abruptly. Overall, Baclofen is a vital medication in managing spasticity, with a well-established profile in clinical use.
Formula:C10H12ClNO2
InChI:InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key:InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES:C(CC(O)=O)(CN)C1=CC=C(Cl)C=C1
Synonyms:- (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- (3S)-4-amino-3-(4-chlorophenyl)butanoic acid
- 4-Amino-3-(4-Chlorophenyl)Butanoic Acid
- 4-Amino-3-(4-Chlorophenyl)Butyric Acid
- 4-Amino-3-(p-chlorophenyl)butyric acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-4-Amino-3-p-chlorophenylbutanoic acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Baclofen
- Atrofen
- Ba 34647
- Baclofene
- Baclofeno
- Baclon
- Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
- Beta-(4-Chlorophenyl)-Gamma-Aminobutyric Acid
- Beta-(4-Chlorophenyl)Gaba
- Beta-(Aminomethyl)-4-Chlorobenzenepropanoic Acid
- Beta-(Aminomethyl)-P-Chlorohydrocinnamic Acid
- C 34647Ba
- CIBA Ba 34647
- Ciba 34,647-Ba
- DL-4-Amino-3-p-chlorophenylbutanoic acid
- Gamma-Amino-Beta-(P-Chlorophenyl)Butyric Acid
- Hydrocinnamic acid, β-(aminomethyl)-p-chloro-
- Lioresal
- dl-Baclofen
- β-(4-Chlorophenyl)-γ-aminobutyric acid
- β-(Aminomethyl)-4-chlorobenzenepropanoic acid
- β-(Aminomethyl)-p-chlorohydrocinnamic acid
- β-(p-Chlorophenyl)-γ-aminobutyric acid
- See more synonyms
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Baclofen
CAS:Formula:C10H12ClNO2Purity:>98.0%(T)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:213.66(+/-)-Baclofen, 99+%
CAS:Selective GABA-b receptor agonistFormula:C10H12ClNO2Purity:99+%Molecular weight:213.66Baclofen
CAS:BaclofenFormula:C10H12CINO2Purity:99.6%Color and Shape:Off WhiteMolecular weight:316.99128Baclofen
CAS:Aromatic amino-acids and their esters,other than those containing more than one kind of oxygen function for use as drugsFormula:C10H12ClNO2Color and Shape:White PowderMolecular weight:213.05566Baclofen
CAS:Baclofen (Lioresal), a chlorophenyl-butanoic acid derivative, treats spasms from spinal cord injury and MS by mimicking GABA at GABA-B receptors.Formula:C10H12ClNO2Purity:98% - 99.94%Color and Shape:White SolidMolecular weight:213.661Baclofen 0.5 mg/ml in Methanol
CAS:Formula:C10H12ClNO2Color and Shape:ColourlessMolecular weight:213.66Baclofen, 1mg/ml in Acetonitrile/Water : 1/1
CAS:Formula:C10H12ClNO2Color and Shape:ColourlessMolecular weight:213.66Baclofen 0.5 mg/ml in Methanol
CAS:Formula:C10H12ClNO2Color and Shape:Colourless LiquidMolecular weight:213.66Baclofen
CAS:Controlled ProductApplications Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985); Brogden, R.N., et al.: Drugs, 8,1 (1974);Formula:C10H12ClNO2Color and Shape:NeatMolecular weight:213.66
