CAS 1134-47-0

Baclofen

Description:

Baclofen is a pharmaceutical compound primarily used as a muscle relaxant and antispastic agent. It is classified as a gamma-aminobutyric acid (GABA) derivative, functioning as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity. This mechanism makes it effective in treating conditions such as multiple sclerosis and spinal cord injuries, where muscle spasticity is prevalent. Baclofen is typically administered orally or via intrathecal delivery for severe cases. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can influence its bioavailability. Its molecular formula is C10H12ClNO2, and it has a moderate molecular weight. Baclofen's pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Side effects may include drowsiness, dizziness, and potential withdrawal symptoms if discontinued abruptly. Overall, Baclofen is a vital medication in managing spasticity, with a well-established profile in clinical use.

Formula: C₁₀H₁₂ClNO₂

InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

InChI key: InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N

SMILES: C(CC(O)=O)(CN)C1=CC=C(Cl)C=C1

Synonyms:

• (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• (3S)-4-amino-3-(4-chlorophenyl)butanoic acid
• 4-Amino-3-(4-Chlorophenyl)Butanoic Acid
• 4-Amino-3-(4-Chlorophenyl)Butyric Acid
• 4-Amino-3-(p-chlorophenyl)butyric acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-4-Amino-3-p-chlorophenylbutanoic acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Baclofen
• Atrofen
• Ba 34647
• Baclofene
• Baclofeno
• Baclon
• Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
• Beta-(4-Chlorophenyl)-Gamma-Aminobutyric Acid
• Beta-(4-Chlorophenyl)Gaba
• Beta-(Aminomethyl)-4-Chlorobenzenepropanoic Acid
• Beta-(Aminomethyl)-P-Chlorohydrocinnamic Acid
• C 34647Ba
• CIBA Ba 34647
• Ciba 34,647-Ba
• DL-4-Amino-3-p-chlorophenylbutanoic acid
• Gamma-Amino-Beta-(P-Chlorophenyl)Butyric Acid
• Hydrocinnamic acid, β-(aminomethyl)-p-chloro-
• Lioresal
• dl-Baclofen
• β-(4-Chlorophenyl)-γ-aminobutyric acid
• β-(Aminomethyl)-4-chlorobenzenepropanoic acid
• β-(Aminomethyl)-p-chlorohydrocinnamic acid
• β-(p-Chlorophenyl)-γ-aminobutyric acid

Baclofen

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Purity: >98.0%(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 213.66

Ref: 3B-B3343

(+/-)-Baclofen, 99+%

CAS: 1134-47-0

Selective GABA-b receptor agonist

Formula: C₁₀H₁₂ClNO₂

Purity: 99+%

Molecular weight: 213.66

Ref: 02-J62768

Baclofen, 1mg/ml in Acetonitrile/Water : 1/1

CAS: 1134-47-0

Color and Shape: Colourless

Ref: LP-BCL-1653-1LAH

Baclofen

CAS: 1134-47-0

Color and Shape: Neat

Ref: 61-FOR1235.00

Baclofen 0.5 mg/ml in Methanol

CAS: 1134-47-0

Color and Shape: Colourless Liquid

Ref: 61-AMP1235.00-08

Baclofen

CAS: 1134-47-0

Color and Shape: Off White

Ref: LP-BCL-1653-10

Baclofen

CAS: 1134-47-0

Baclofen

Formula: C₁₀H₁₂CINO₂

Purity: 99.6%

Color and Shape: Off White

Molecular weight: 316.99128

Ref: 47-28

BACLOFEN CRS

CAS: 1134-47-0

BACLOFEN CRS

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.6608

Ref: 41-B0200000

Baclofen

CAS: 1134-47-0

Aromatic amino-acids and their esters,other than those containing more than one kind of oxygen function for use as drugs

Formula: C₁₀H₁₂ClNO₂

Color and Shape: White Powder

Molecular weight: 213.05566

Ref: 45-1048200

Baclofen

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.6608

Ref: IN-DA003NYH

Baclofen

CAS: 1134-47-0

Baclofen (Lioresal), a chlorophenyl-butanoic acid derivative, treats spasms from spinal cord injury and MS by mimicking GABA at GABA-B receptors.

Formula: C₁₀H₁₂ClNO₂

Purity: 98% - 99.94%

Color and Shape: 1992)

Molecular weight: 213.66

Ref: TM-T1065

Baclofen

CAS: 1134-47-0

Baclofen

Formula: C₁₀H₁₂ClNO₂

Purity: ≥98%

Molecular weight: 213.66

Ref: 54-BUP17874

Baclofen

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: 4Z-B-4025

Baclofen

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: 7W-GP4566

Baclofen

CAS: 1134-47-0

Baclofen

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Molecular weight: 213.66

Ref: 54-OR1029079

Baclofen

Controlled Product

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 213.66

Ref: 04-C10418050

Baclofen

Controlled Product

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 213.66

Ref: 86-MM1235.00

Baclofen

CAS: 1134-47-0

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: ST-EA-CP-B3000

Dibaclofen Urea Dicyclohexylammonium Salt

Controlled Product

CAS: 1134-47-0

Applications Dibaclofen Urea Dicyclohexylammonium Salt, is an impurity of Baclofen (B108000), which is an specific GABA-B receptor agonist, and muscle relaxant (skeletal). It is primarily used to treat spasticity.
References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)

Formula: C₂₁H₂₀Cl₂N₂O₅·2C₁₂H₂₄N

Color and Shape: Neat

Molecular weight: 815.951

Ref: TR-D417365

Baclofen

Controlled Product

CAS: 1134-47-0

Applications Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985); Brogden, R.N., et al.: Drugs, 8,1 (1974);

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 213.66

Ref: TR-B108000