CAS 113559-13-0

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide hydrochloride (1:2)

Description:

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide hydrochloride (1:2), with CAS number 113559-13-0, is a chemical compound characterized by its complex structure, which includes a sulfonamide functional group and a piperidine ring. This compound is typically used in pharmaceutical applications, often as a potential therapeutic agent due to its ability to interact with biological targets. The presence of the pyridine moiety suggests potential interactions with various receptors or enzymes, making it of interest in medicinal chemistry. The hydrochloride salt form indicates enhanced solubility in aqueous environments, which is beneficial for drug formulation. Its molecular structure contributes to its pharmacokinetic properties, influencing absorption, distribution, metabolism, and excretion (ADME). As with many sulfonamides, it may exhibit antibacterial properties, although specific biological activities would depend on further empirical studies. Safety and handling precautions are essential, as with all chemical substances, to mitigate any potential hazards associated with its use.

Formula: C₂₁H₂₇N₃O₃S·2ClH

InChI: InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H

InChI key: InChIKey=ZQBNWMFBOSOOLX-UHFFFAOYSA-N

SMILES: C(=O)(C1=CC=C(NS(C)(=O)=O)C=C1)C2CCN(CCC=3N=C(C)C=CC3)CC2.Cl

Synonyms:

• E 4031
• Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, dihydrochloride
• Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2)
• N-[4-({1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl}carbonyl)phenyl]methanesulfonamide dihydrochloride
• N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide hydrochloride (1:2)
• N-[4-({1-[2-(6-Methylpyridin-2-yl)ethyl]piperidin-4-yl}carbonyl)phenyl]methanesulfonamide dihydrochloride

Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2)

CAS: 113559-13-0

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: 99%

Color and Shape: Solid

Molecular weight: 474.4443

Ref: IN-DA0008YW

E-4031

CAS: 113559-13-0

E-4031

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: ≥95%

Molecular weight: 474.44

Ref: 54-BUP05788

E-4031

CAS: 113559-13-0

Formula: C₂₁H₂₇N₃O₃S·2HCl

Molecular weight: 474.44

Ref: 7W-GK8239

N-(4-(1-(2-(6-MEthylpyridin-2-yl)Ethyl)Piperidine-4-Carbonyl)Phenyl)Methanesulfonamide Dihydrochloride

CAS: 113559-13-0

N-(4-(1-(2-(6-MEthylpyridin-2-yl)Ethyl)Piperidine-4-Carbonyl)Phenyl)Methanesulfonamide Dihydrochloride

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: 99%

Molecular weight: 474.44

Ref: 54-OR1023223

E-4031 dihydrochloride

CAS: 113559-13-0

E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: 99.31% - 99.87%

Color and Shape: White Solid

Molecular weight: 474.44

Ref: TM-T7198

E-4031

CAS: 113559-13-0

N-(4-(1-(2-(6-Methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide dihydrochloride

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: 99%

Molecular weight: 474.44

Ref: IN-DG231837

E-4031 Dihydrochloride

CAS: 113559-13-0

Formula: C₂₁H₂₉Cl₂N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 474.44

Ref: 10-F047214

E-4031 dihydrochloride

Controlled Product

CAS: 113559-13-0

Stability Hygroscopic
Applications E-4031 dihydrochloride is a K+ channel blocker that spawned a class of antiarrhythmic molecules.

Formula: C₂₁H₂₇N₃O₃S•2HCl

Color and Shape: Neat

Molecular weight: 401.5223646

Ref: TR-D453908

E-4031

CAS: 113559-13-0

E-4031 is a drug that belongs to the class of ryanodine receptor antagonists. It is a potent inhibitor of the calcium release from intracellular stores and has been shown to be effective in experimental models of cardiac disease. E-4031 has been shown to have cardiac effects such as a decrease in heart rate and blood pressure, while having no effect on the contractility of the heart. E-4031 also inhibits myocardial infarct size and improves left ventricular function following an experimental myocardial infarction. These effects are due to its ability to inhibit calcium overload in cardiomyocytes by decreasing calcium levels inside the cell and preventing Ca2+ overload.

Formula: C₂₁H₂₇N₃O₃S·2HCl

Purity: Min. 95%

Molecular weight: 474.44 g/mol

Ref: 3D-NEA55913