CAS 113665-84-2

Clopidogrel

Description:

Clopidogrel is an antiplatelet medication primarily used to prevent blood clots in patients with cardiovascular diseases, such as those who have experienced a heart attack or stroke. It functions as a prodrug, meaning it requires metabolic activation to exert its therapeutic effects. Clopidogrel selectively inhibits the P2Y12 adenosine diphosphate (ADP) receptor on platelets, thereby preventing platelet aggregation. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract, although its bioavailability is affected by first-pass metabolism. Clopidogrel is characterized by its relatively low solubility in water and is often formulated as a bisulfate salt to enhance its stability and absorption. The drug has a half-life of approximately 8 hours, but its antiplatelet effects can last for several days due to irreversible binding to the P2Y12 receptor. Common side effects may include bleeding complications, gastrointestinal disturbances, and, in rare cases, hypersensitivity reactions. Overall, Clopidogrel plays a crucial role in the management of thrombotic disorders.

Formula: C₁₆H₁₆ClNO₂S

InChI: InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1

InChI key: InChIKey=GKTWGGQPFAXNFI-HNNXBMFYSA-N

SMILES: [C@H](C(OC)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3

Synonyms:

• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (S)-
• Clopidogrel
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-
• (S)-Methyl α-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-α-(o-chlorophenyl)acetate
• (S)-(+)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate

(S)-(+)-Clopidogrel Sulfate

CAS: 113665-84-2, 120202-66-6

Formula: C₁₆H₁₆ClNO₂S·H₂SO₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 419.89

Ref: 3B-C2556

Clopidogrel

CAS: 113665-84-2

Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.

Formula: C₁₆H₁₆ClNO₂S

Purity: 98.23% - 98.83%

Color and Shape: White Powder

Molecular weight: 321.82

Ref: TM-T0182

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-

CAS: 113665-84-2

Formula: C₁₆H₁₆ClNO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 321.8217

Ref: IN-DA00099Q

Clopidogrel

CAS: 113665-84-2

Clopidogrel

Purity: ≥98%

Molecular weight: 321.82g/mol

Ref: 54-BUP17398

(S)-Methyl 2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-Yl)Acetate

CAS: 113665-84-2

(S)-Methyl 2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-Yl)Acetate

Purity: 98%

Molecular weight: 321.82g/mol

Ref: 54-OR1027848

Clopidogrel

CAS: 113665-84-2

Formula: C₁₆H₁₆ClNO₂S

Purity: ≥ 90.0%

Color and Shape: Light yellow viscous liquid

Molecular weight: 321.82

Ref: 7W-GP2599

(S)-Clopidogrel

CAS: 113665-84-2

Color and Shape: Neat

Ref: 04-C11686930

Clopidogrel

CAS: 113665-84-2

Formula: C₁₆H₁₆ClNO₂S

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White or Colorless to Light yellow to Light orange powder to lump to clear liquid

Molecular weight: 321.82

Ref: 3B-C3946

Clopidogrel

Controlled Product

CAS: 113665-84-2

Methyl (2S)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acetate, also know as Clopidogrel, is a potent inhibitor of the platelet aggregation. It reduces blood clotting by inhibiting the ADP receptor on the surface of platelets, thereby inhibiting the aggregation and adhesion of platelets. Clopidogrel has been shown to be effective in preventing thrombosis, myocardial infarction (heart attack), and stroke. Clopidogrel inhibits the activity of cytochrome P450 3A4 (CYP3A4) and p2Y 12 receptors. Clopidogrel has been shown to have synergic effects with nonsteroidal anti-inflammatory drugs (NSAIDs). The polymorphic nature of Clopidogrel can be monitored using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification in biological samples such as human serum and plasma.

Formula: C₁₆H₁₆ClNO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 321.82 g/mol

Ref: 3D-FM61519