CAS 113866-14-1

BOC-GRR-AMC

Description:

BOC-GRR-AMC, with the CAS number 113866-14-1, is a chemical compound that serves as a substrate in biochemical assays, particularly in the study of proteases. It is characterized by the presence of a BOC (tert-butyloxycarbonyl) protecting group, which is commonly used in peptide synthesis to protect amino groups. The GRR sequence indicates the presence of specific amino acids, likely arginine and glycine, which can be relevant for enzyme specificity. The AMC (7-amino-4-methylcoumarin) moiety is a fluorogenic group that emits fluorescence upon cleavage, making it useful for monitoring enzymatic activity in real-time. This compound is typically utilized in research settings to investigate proteolytic activity and enzyme kinetics. Its stability, solubility in organic solvents, and the ability to provide a measurable fluorescent signal upon reaction make it a valuable tool in biochemical and pharmaceutical research. Proper handling and storage conditions are essential to maintain its integrity and reactivity.

Formula: C₂₉H₄₄N₁₀O₇

Synonyms:

• T-Butyloxycarbonylglycyl-L-Arginyl-L-Arginine 4-Methylcoumaryl-7-Amide
• Boc-Gly-Arg-Arg-Mca
• Boc-Gly-Arg-Arg-Amc
• tert-butyl N-[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate
• BOC-GRR-AMC
• L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• TERT-BUTYLOXYCARBONYL-GLYCYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE

Boc-Gly-Arg-Arg-AMC

CAS: 113866-14-1

A substrate for flavivirus proteases such as West Nile virus protease, yellow fever virus NS3 protease, and dengue virus NS2B-NS3 protease.Boc-GRR-AMC is cleaved by type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana. Stock solutions of Boc-GRR-AMC are best prepared in DMSO.

Formula: C₂₉H₄₄N₁₀O₇

Purity: 98.7%

Color and Shape: White Powder

Molecular weight: 644.73

Ref: 01-4017086

Boc-Gly-Arg-Arg-AMC acetate salt

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC acetate salt is a protease inhibitor that inhibits the activity of serine proteases. This protein is a potent and selective inhibitor of the NS3 protease from hepatitis C virus, which is responsible for the cleavage of polyproteins into mature proteins. Boc-Gly-Arg-Arg-AMC acetate salt has been shown to be effective in transfection experiments and polymerase chain reaction, as well as in inhibiting the activity of soybean trypsin and mammalian tissue proteases.

Formula: C₂₉H₄₄N₁₀O₇•(C₂H₄O₂)x

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 644.72 g/mol

Ref: 3D-FB110553

Boc-Gly-Arg-Arg-AMC

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC is a research tool that has a high purity and is used in cell biology, antibody production, ion channels, and protein interactions. It is an inhibitor of ion channels, which can be used for pharmacology to study the function of ion channels. Boc-Gly-Arg-Arg-AMC has also been shown to inhibit binding between the ligand and receptor.

Formula: C₂₉H₄₄N₁₀O₇

Purity: Min. 95%

Molecular weight: 644.72 g/mol

Ref: 3D-MGR-3142-V

Boc-Gly-Arg-Arg-AMC trifluoroacetate

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC trifluoroacetate is a potent inhibitor of kinases, which are enzymes that play a crucial role in various cellular processes. It has been shown to effectively inhibit the activity of both Chinese and human kinases. This inhibitor has also demonstrated its efficacy as an anticancer agent by inducing apoptosis in cancer cells. Boc-Gly-Arg-Arg-AMC trifluoroacetate is a medicinal protein analog that can be used for the development of novel inhibitors with improved potency and selectivity. Its potential therapeutic applications make it a promising candidate for cancer treatment. Additionally, this compound can be detected in urine, making it an excellent biomarker for kinase activity in vivo.

Formula: C₂₉H₄₄N₁₀O₇•(C₂HF₃O₂)x

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-BB183183