CAS 113942-30-6

Temozolomideacid

Description:

Temozolomide, with the CAS number 113942-30-6, is an oral alkylating agent primarily used in the treatment of certain types of brain tumors, particularly glioblastoma multiforme and anaplastic astrocytoma. It is a prodrug that is converted in the body to the active compound, which methylates DNA, leading to cell death, particularly in rapidly dividing cancer cells. Temozolomide is characterized by its ability to cross the blood-brain barrier, making it effective for central nervous system tumors. The compound is typically administered in capsule form and is known for its relatively favorable side effect profile compared to traditional chemotherapeutics, although it can still cause nausea, fatigue, and myelosuppression. Its mechanism of action involves the formation of O6-methylguanine, which mispairs during DNA replication, ultimately triggering apoptosis in tumor cells. Temozolomide is often used in combination with radiotherapy and has been a significant advancement in the management of malignant brain tumors.

Formula: C₆H₇N₅O₃

InChI: InChI=1/C6H7N5O3/c1-10-6(14)11-2-7-3(5(12)13)4(11)8-9-10/h2-4H,1H3,(H,12,13)

SMILES: CN1C(=O)N2C=NC(C2N=N1)C(=O)O

Temozolomide Acid

CAS: 113942-30-6

Formula: C₆H₅N₅O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 195.14

Ref: 3B-T3686

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo-

CAS: 113942-30-6

Formula: C₆H₅N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 195.1356

Ref: IN-DA000A4I

Temozolomide acid

CAS: 113942-30-6

Temozolomide acid

Purity: 98%

Molecular weight: 195.137g/mol

Ref: 54-OR1002583

Temozolomide Acid

CAS: 113942-30-6

Temozolomide Acid

Purity: ≥98%

Molecular weight: 195.14g/mol

Ref: 54-BUP16692

Temozolomide EP Impurity B (Temozolomide Acid)

CAS: 113942-30-6

Formula: C₆H₅N₅O₃

Color and Shape: Off-White Solid

Molecular weight: 195.14

Ref: 4Z-T-345

Temozolomide Acid

CAS: 113942-30-6

TMZA, a TMZ metabolite, shows in vitro anticancer effects. TMZ, an oral alkylator, treats GBM and astrocytomas.

Formula: C₆H₅N₅O₃

Purity: 99.28%

Color and Shape: Solid

Molecular weight: 195.14

Ref: TM-T21463

Temozolomide Acid

CAS: 113942-30-6

Stability Hygroscopic
Applications A metabolite of Temozolomide (T017775) as antitumor agent.
References Schulman, M., et al.: J. Biol. Chem., 196, 513 (1952), Stevens, M., et al.: Cancer Res., 47, 5846 (1987), Baker, S., et al.: Clin. Cancer Res., 5, 309 (1999),

Formula: C₆H₅N₅O₃

Color and Shape: White to Off-White Solid

Molecular weight: 195.14

Ref: TR-T017780

Temozolomide EP Impurity B

CAS: 113942-30-6

Formula: C₆H₅N₅O₃

Molecular weight: 195.14

Ref: ST-EA-CP-T15002

Temozolomide acid

CAS: 113942-30-6

Temozolomide acid is a cytotoxic anticancer compound that has been shown to inhibit the growth of cancer cells in vitro. It is an acid, which may be hydrolyzed by enzymes in the skin, so it should not be used for external application. Temozolomide acid has been shown to show anti-cancer activity against primary cells and tumour cells, but not normal cells. This may be due to its ability to inhibit the action of growth factors on integrin receptors found on tumor cells.

Formula: C₆H₅N₅O₃

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 195.14 g/mol

Ref: 3D-FT63449

3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid

CAS: 113942-30-6

Formula: C₆H₅N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 195.138

Ref: 10-F237935