CAS 113942-30-6
:Temozolomideacid
Description:
Temozolomide, with the CAS number 113942-30-6, is an oral alkylating agent primarily used in the treatment of certain types of brain tumors, particularly glioblastoma multiforme and anaplastic astrocytoma. It is a prodrug that is converted in the body to the active compound, which methylates DNA, leading to cell death, particularly in rapidly dividing cancer cells. Temozolomide is characterized by its ability to cross the blood-brain barrier, making it effective for central nervous system tumors. The compound is typically administered in capsule form and is known for its relatively favorable side effect profile compared to traditional chemotherapeutics, although it can still cause nausea, fatigue, and myelosuppression. Its mechanism of action involves the formation of O6-methylguanine, which mispairs during DNA replication, ultimately triggering apoptosis in tumor cells. Temozolomide is often used in combination with radiotherapy and has been a significant advancement in the management of malignant brain tumors.
Formula:C6H7N5O3
InChI:InChI=1/C6H7N5O3/c1-10-6(14)11-2-7-3(5(12)13)4(11)8-9-10/h2-4H,1H3,(H,12,13)
SMILES:CN1C(=O)N2C=NC(C2N=N1)C(=O)O
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Found 11 products.
Temozolomide Acid
CAS:Formula:C6H5N5O3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:195.14Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo-
CAS:Formula:C6H5N5O3Purity:98%Color and Shape:SolidMolecular weight:195.1356Temozolomide Acid
CAS:Temozolomide AcidFormula:C6H5N5O3Purity:≥98%, 10 mM in DMSOMolecular weight:195.14Temozolomide EP Impurity B (Temozolomide Acid)
CAS:Formula:C6H5N5O3Color and Shape:Off-White SolidMolecular weight:195.14Temozolomide Acid
CAS:TMZA, a TMZ metabolite, shows in vitro anticancer effects. TMZ, an oral alkylator, treats GBM and astrocytomas.Formula:C6H5N5O3Purity:99.28%Color and Shape:SolidMolecular weight:195.14Temozolomide acid
CAS:3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acidFormula:C6H5N5O3Purity:98%Molecular weight:195.14Temozolomide Acid
CAS:Stability Hygroscopic
Applications A metabolite of Temozolomide (T017775) as antitumor agent.
References Schulman, M., et al.: J. Biol. Chem., 196, 513 (1952), Stevens, M., et al.: Cancer Res., 47, 5846 (1987), Baker, S., et al.: Clin. Cancer Res., 5, 309 (1999),Formula:C6H5N5O3Color and Shape:White to Off-White SolidMolecular weight:195.14Temozolomide acid
CAS:Temozolomide acid is a cytotoxic anticancer compound that has been shown to inhibit the growth of cancer cells in vitro. It is an acid, which may be hydrolyzed by enzymes in the skin, so it should not be used for external application. Temozolomide acid has been shown to show anti-cancer activity against primary cells and tumour cells, but not normal cells. This may be due to its ability to inhibit the action of growth factors on integrin receptors found on tumor cells.Formula:C6H5N5O3Purity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:195.14 g/mol3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid
CAS:Formula:C6H5N5O3Purity:95%Color and Shape:SolidMolecular weight:195.138
![Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000A4I.jpg&w=3840&q=75)
![3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb%2FF237935.jpg&w=3840&q=75)
