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CAS 114-86-3

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Phenformin

Description:
Phenformin is a biguanide derivative, primarily recognized for its role as an antihyperglycemic agent in the management of type 2 diabetes mellitus. It is characterized by its ability to decrease hepatic glucose production and enhance insulin sensitivity, thereby improving glucose uptake in peripheral tissues. Phenformin is known for its lipophilic nature, which allows it to penetrate cell membranes effectively. The compound has a relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. It is also associated with a risk of lactic acidosis, a serious side effect that has led to its withdrawal from the market in many countries. In terms of chemical structure, Phenformin features a biguanide backbone, which is essential for its biological activity. Its molecular formula reflects its composition of carbon, hydrogen, nitrogen, and oxygen atoms. Overall, while Phenformin has demonstrated efficacy in glycemic control, its safety profile has limited its clinical use in favor of other antidiabetic medications.
Formula:C10H15N5
InChI:InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
InChI key:InChIKey=ICFJFFQQTFMIBG-UHFFFAOYSA-N
SMILES:C(CNC(NC(=N)N)=N)C1=CC=CC=C1
Synonyms:
  • (Phenylethyl)biguanide
  • 1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine
  • 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide
  • 1-Phenethylbiguanide
  • Biguanide, 1-phenethyl-
  • Cronoformin
  • DB Comb.
  • DB-retard
  • DBI
  • Debeone
  • See more synonyms
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