CAS 1140964-99-3

3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-

CAS: 1140964-99-3

Formula: C₁₈H₁₅N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.3446

Ref: IN-DA000AK3

E7449

CAS: 1140964-99-3

E7449

Purity: ≥95%

Molecular weight: 317.34g/mol

Ref: 54-BUP09482

E7449

CAS: 1140964-99-3

E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.

Formula: C₁₈H₁₅N₅O

Purity: 97.13%

Color and Shape: Solid

Molecular weight: 317.34

Ref: TM-T4471

E 7449

CAS: 1140964-99-3

E 7449 is a p-glycoprotein (p-gp) substrate that inhibits the function of this transporter. It has been shown to inhibit macrophage inflammatory protein 2 in vitro, which could be due to its effects on the metabolic rate. E 7449 has also been shown to have anti-inflammatory effects in vivo and to reduce the severity of bowel disease in a rat model. This drug has also shown promising results when used as a co-therapy with platinum-based chemotherapy for solid tumours.

Formula: C₁₈H₁₅N₅O

Purity: Min. 95%

Molecular weight: 317.34 g/mol

Ref: 3D-QVB96499