CAS 1140964-99-3

Formula: C18H15N5O

InChI: InChI=1S/C18H15N5O/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23/h1-7H,8-10H2,(H,22,24)(H,19,20,21)

InChI key: JLFSBHQQXIAQEC-UHFFFAOYSA-N

SMILES: C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3

E7449

CAS: 1140964-99-3

E7449

Formula: C₁₈H₁₅N₅O

Purity: ≥95%

Molecular weight: 317.34

Ref: 54-BUP09482

E 7449

CAS: 1140964-99-3

Formula: C₁₈H₁₅N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.3446

Ref: IN-DA000AK3

Stenoparib

CAS: 1140964-99-3

8-(Isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one

Formula: C₁₈H₁₅N₅O

Purity: 98%

Molecular weight: 317.34

Ref: IN-DG629929

E7449

CAS: 1140964-99-3

E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.

Formula: C₁₈H₁₅N₅O

Purity: 98.84%

Color and Shape: White Solid

Molecular weight: 317.3446

Ref: TM-T4471

E 7449

CAS: 1140964-99-3

E 7449 is a p-glycoprotein (p-gp) substrate that inhibits the function of this transporter. It has been shown to inhibit macrophage inflammatory protein 2 in vitro, which could be due to its effects on the metabolic rate. E 7449 has also been shown to have anti-inflammatory effects in vivo and to reduce the severity of bowel disease in a rat model. This drug has also shown promising results when used as a co-therapy with platinum-based chemotherapy for solid tumours.

Formula: C₁₈H₁₅N₅O

Purity: Min. 95%

Molecular weight: 317.34 g/mol

Ref: 3D-QVB96499