CAS 1143-38-0

Dithranol

Description:

Dithranol, also known as anthralin, is an organic compound primarily used in dermatological applications, particularly for the treatment of psoriasis. It appears as a yellow to brown crystalline solid and is known for its anti-inflammatory and keratolytic properties. Dithranol functions by inhibiting the proliferation of skin cells and promoting the normalization of skin differentiation, which is beneficial in managing psoriatic lesions. The compound is typically applied topically and can be formulated in various concentrations, depending on the severity of the condition being treated. It is important to note that dithranol can cause skin irritation and staining, necessitating careful application and handling. Additionally, it is sensitive to light and air, which can affect its stability and efficacy. As a chemical substance, dithranol has a relatively low solubility in water but is soluble in organic solvents, making it suitable for incorporation into various topical formulations. Overall, dithranol remains a valuable therapeutic agent in dermatology, particularly for chronic skin conditions.

Formula: C₁₄H₁₀O₃

InChI: InChI=1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

InChI key: InChIKey=NUZWLKWWNNJHPT-UHFFFAOYSA-N

SMILES: O=C1C=2C(CC=3C1=C(O)C=CC3)=CC=CC2O

Synonyms:

• 1,8-Dihydroxy-10H-anthracen-9-one
• 1,8-Dihydroxy-9,10-dihydroanthracen-9-one
• 1,8-Dihydroxy-9-Anthrone
• 1,8-Dihydroxy-Anthrone
• 1,8-Dihydroxyanthracen-9(10H)-on
• 1,8-Dihydroxyanthrone
• 1,8-dihidroxiantracen-9(10H)-ona
• 1,8-dihydroxy-9(10H)-anthracenone
• 1,8-dihydroxyanthracen-9(10H)-one
• 1,8-dihydroxyanthracene-9(10H)-one
• 9(10H)-Anthracenone, 1,8-dihydroxy-
• Anthra-Derm
• Anthracene-1,8,9-Triol
• Anthralin
• Anthrone, 1,8-dihydroxy-
• Batidrol
• Batridol
• Batridrol
• Chrysodermol
• Cignolin
• Cigthranol
• Cygnolin
• Dermaline
• Derobin
• DithraSal
• Dithrocream
• DrithoCreme
• Drithoscalp
• Lasan
• Nsc 43970
• Nsc 629313
• Psodadrate
• Psoriacid-Stift
• Psoriacide

Dithranol

CAS: 1143-38-0, 480-22-8

Formula: C₁₄H₁₀O₃

Purity: >95.0%(T)(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 226.23

Ref: 3B-T1166

DITHRANOL CRS

CAS: 1143-38-0

DITHRANOL CRS

Formula: C₁₄H₁₀O₃

Color and Shape: Crystalline Powder. Yellow. Dark. Powder.

Molecular weight: 226.2274

Ref: 41-D2953000

Dithranol

CAS: 1143-38-0

Dithranol

Formula: C₁₄H₁₀O₃

Purity: 98.8%

Color and Shape: Yellow-Red Powder

Molecular weight: 226.06299

Ref: 47-385

Anthralin

CAS: 1143-38-0

Ketone-phenols and ketones with other oxygen function

Formula: C₁₄H₁₀O₃

Color and Shape: Yellow Brownish Yellow Microcrystalline Powder

Molecular weight: 226.06299

Ref: 45-1039006

Dithranol

CAS: 1143-38-0

Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially

Formula: C₁₄H₁₀O₃

Purity: 93.49% - 99.33%

Color and Shape: Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder Melting

Molecular weight: 226.23

Ref: TM-T1068

9(10H)-Anthracenone, 1,8-dihydroxy-

CAS: 1143-38-0

Formula: C₁₄H₁₀O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 226.2274

Ref: IN-DA000B10

Dithranol

CAS: 1143-38-0

Formula: C₁₄H₁₀O₃

Purity: (Titration) 96.0 - 103.0 % (dried basis)

Color and Shape: Yellow to orange-brown crystalline powder

Molecular weight: 226.23

Ref: 7W-GC2421

Dithranol, EP grade

CAS: 1143-38-0

Formula: C₁₄H₁₀O₃

Purity: ≤ 2.5%

Color and Shape: Yellow or brown-yellow crystalline powder

Molecular weight: 226.23

Ref: 7W-GC9801

1,8-Dihydroxyanthracen-9(10H)-One

CAS: 1143-38-0

1,8-Dihydroxyanthracen-9(10H)-One

Purity: 98%

Molecular weight: 226.23g/mol

Ref: 54-OR1009295

Dithranol

CAS: 1143-38-0

Dithranol

Purity: ≥90%

Molecular weight: 226.23g/mol

Ref: 54-BUP14808

Dithranol

Controlled Product

CAS: 1143-38-0

Formula: C₁₄H₁₀O₃

Color and Shape: Neat

Molecular weight: 226.23

Ref: 04-C13013900

Dithranol

Controlled Product

CAS: 1143-38-0

Formula: C₁₄H₁₀O₃

Color and Shape: Neat

Molecular weight: 226.23

Ref: 86-MM0137.00

Anthralin

CAS: 1143-38-0

Anthralin is a synthetic retinoid that has been used to treat bowel diseases such as ulcerative colitis and Crohn's disease. Anthralin belongs to a class of drugs called "reactive" or "synthetic" retinoids, which are chemically similar to the natural form of vitamin A. It is thought that anthralin may work by altering the permeability of the cell membrane, which leads to an increase in reactive oxygen species and a decrease in mitochondrial membrane potential. In vivo studies on humans have shown that it can be used as a treatment for mild-to-moderate disease activity in ulcerative colitis, but not Crohn's disease. Anthralin has also been found to be effective at reducing the side effects of corticosteroids when used with them in combination therapy.

Formula: C₁₄H₁₀O₃

Purity: Min. 95 Area-%

Color and Shape: Yellow Powder

Molecular weight: 226.23 g/mol

Ref: 3D-FA17945

Anthralin

Controlled Product

CAS: 1143-38-0

Stability Hygroscopic
Applications Antipsoriatic.
References Ashton, R.E., et al.: J. Am. Acad. Dermatol., 9, 173 (1983), Kemeny, L., et al.: Skin Pharmacol., 3, 1 (1990), Mahrle, G., et al.: Clin. Dermatol., 15, 723 (1997)

Formula: C₁₄H₁₀O₃

Color and Shape: Yellow-Orange

Molecular weight: 226.23

Ref: TR-A679200