CAS 114360-54-2

fmoc-D-leucine

Description:

Fmoc-D-leucine, with the CAS number 114360-54-2, is a derivative of the amino acid leucine, modified with a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is characterized by its white to off-white crystalline appearance and is commonly used in peptide synthesis as a protective group for the amino group of the amino acid. The Fmoc group is stable under basic conditions but can be removed under acidic conditions, allowing for selective deprotection during the synthesis of peptides. Fmoc-D-leucine is particularly notable for its role in the synthesis of peptides that require the incorporation of D-amino acids, which can influence the biological activity and stability of the resulting peptides. Its solubility is generally good in organic solvents, making it suitable for various synthetic applications. Additionally, the presence of the D-isomer can impart unique properties to peptides, such as resistance to enzymatic degradation, which is valuable in pharmaceutical development.

Formula: C₂₁H₂₃NO₄

InChI: InChI=1/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m1/s1

SMILES: CC(C)C[C@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12

Synonyms:

• Fmoc-D-Leu-OH
• NALPHA-9-Fluorenylmethoxycarbonyl-D-leucine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]leucine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-leucine

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 353.42

Ref: 3B-F0603

N-Fmoc-D-leucine, 98%

CAS: 114360-54-2

A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Powder, White to pale cream

Molecular weight: 353.42

Ref: 02-H29041

Fmoc-D-Leu-OH

CAS: 114360-54-2

Bachem ID: 4005951.

Formula: C₂₁H₂₃NO₄

Purity: 99.8%

Color and Shape: White

Molecular weight: 353.42

Ref: 01-4005951

D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 353.4116

Ref: IN-DA000B5W

Fmoc-D-Leucine

CAS: 114360-54-2

Fmoc-D-Leucine

Purity: 98%

Molecular weight: 353.41g/mol

Ref: 54-OR1013348

D-Leucine-d10-N-FMOC

CAS: 114360-54-2, 2714483-30-2

Formula: (CD₃)₂CDCD₂CD(NHFMOC)COOH

Purity: 98 atom % D

Molecular weight: 363.48

Ref: 3U-D7978

Fmoc-D-Leu-OH

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Purity: ≥ 99.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 353.42

Ref: 7W-GM1149

Fmoc-D-Leu-OH

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Molecular weight: 353.42

Ref: 4Z-L-117006

Fmoc-D-Leu-OH

CAS: 114360-54-2

Fmoc-D-Leu-OH is a disulfide bond containing molecule with an intracellular Ca2+ chelating activity. It has been shown to have cytoprotective effects against oxidative stress and cell death, and has also been found to have antiinflammatory properties. Fmoc-D-Leu-OH can inhibit the activities of various enzymes such as cyclooxygenase, lipoxygenase, phospholipases, and diamine oxidase. This molecule also exhibits cytotoxic activity against bladder cancer cells in vitro. The pharmacokinetic properties of Fmoc-D-Leu-OH are similar to other molecules that are used as antibiotics.
Fmoc-D-Leu-OH is a cyclic peptide with antimicrobial peptide (AMP) activity that inhibits bacterial growth by disrupting their cell membranes or inhibiting protein synthesis. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading

Formula: C₂₁H₂₃NO₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 353.41 g/mol

Ref: 3D-FF39046

Fmoc-D-Leu-OH

CAS: 114360-54-2

M03366 - Fmoc-D-Leu-OH

Formula: C₂₁H₂₃NO₄

Purity: 97%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 353.418

Ref: 10-M03366

FMOC-D-Leucine extrapure, 99%

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Purity: min. 99.0%

Color and Shape: White, Crystalline powder

Molecular weight: 353.40

Ref: SR-16515

N-Fmoc-D-leucine

CAS: 114360-54-2

Formula: C₂₁H₂₃NO₄

Molecular weight: 353.4

Ref: ST-EA-CP-L28011