CAS 114798-26-4

Losartan

Description:

Losartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension and to protect the kidneys in patients with type 2 diabetes. It is characterized by its ability to selectively block the action of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical formula of Losartan is C22H23ClN6O, and it features a biphenyl structure with a tetrazole ring, contributing to its pharmacological properties. Losartan is typically administered orally and exhibits a relatively long half-life, allowing for once-daily dosing. It is well-absorbed in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. The drug is metabolized primarily in the liver, with its active metabolite contributing to its antihypertensive effects. Common side effects may include dizziness, fatigue, and potential renal impairment, necessitating monitoring in patients with pre-existing kidney conditions. Overall, Losartan is a widely used medication in managing cardiovascular health and offers a favorable safety profile compared to some other antihypertensive agents.

Formula: C₂₂H₂₃ClN₆O

InChI: InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

InChI key: InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N

SMILES: C(N1C(CCCC)=NC(Cl)=C1CO)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

Synonyms:

• 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
• DUP 89
• Losartan

Losartan

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 422.92

Ref: 3B-L0378

Losartan

CAS: 114798-26-4

Losartan

Formula: C₂₂H₂₃ClN₆O

Purity: ≥98%

Molecular weight: 422.91

Ref: 54-BUP19382

Losartan

CAS: 114798-26-4

Losartan (DuP-753) is an angiotensin II receptor antagonist.

Formula: C₂₂H₂₃ClN₆O

Purity: 99.48% - >99.99%

Color and Shape: Solid

Molecular weight: 422.911

Ref: TM-T0215L

Losartan

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 422.91

Ref: 7W-GP6564

(1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Chloro-1H-Imidazol-5-Yl)Methanol

CAS: 114798-26-4

(1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Chloro-1H-Imidazol-5-Yl)Methanol

Formula: C₂₂H₂₃ClN₆O

Purity: 98%

Color and Shape: Solid-Powder

Molecular weight: 422.91

Ref: 54-OR1007790

Losartan

Controlled Product

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Color and Shape: Neat

Molecular weight: 422.91

Ref: 86-MM0168.00

2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 422.9106

Ref: IN-DA000F85

Losartan

Controlled Product

CAS: 114798-26-4

Applications Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990); McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997); Pitt, B., et al.: Lancet, 355, 1582 (2000)

Formula: C₂₂H₂₃ClN₆O

Color and Shape: Neat

Molecular weight: 422.91

Ref: TR-L470470

Losartan

CAS: 114798-26-4

(1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol

Formula: C₂₂H₂₃ClN₆O

Purity: 98%

Molecular weight: 422.91

Ref: IN-DG136688

Losartan

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Molecular weight: 422.92

Ref: ST-EA-CP-L25054

Losartan

CAS: 114798-26-4

Angiotensin II type 1 receptor antagonist

Formula: C₂₂H₂₃ClN₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 422.91 g/mol

Ref: 3D-FL39656

Losartan - Bio-X ™

CAS: 114798-26-4

Losartan is an anti-hypertensive agent that is used to treat hypertension, diabetic nephropathy and has shown to reduce the risk of strokes. This drug is an angiotensin II receptor blocker and works to relax smooth muscles and lower blood pressure.

Formula: C₂₂H₂₃ClN₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 422.91 g/mol

Ref: 3D-BL164640

Losartan

CAS: 114798-26-4

Formula: C₂₂H₂₃ClN₆O

Color and Shape: Solid

Molecular weight: 422.9

Ref: BE-BePure-28868

Losartan

CAS: 114798-26-4

Purity: 99%

Color and Shape: Solid

Molecular weight: 422.162

Ref: 10-F861563