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CAS 114870-03-0

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Fondaparinux

Description:
Fondaparinux is a synthetic anticoagulant that belongs to the class of drugs known as factor Xa inhibitors. It is primarily used for the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. Fondaparinux works by selectively inhibiting factor Xa, an essential component in the coagulation cascade, thereby preventing the formation of blood clots. The substance is characterized by its high bioavailability when administered subcutaneously and a long half-life, allowing for once-daily dosing. Fondaparinux is water-soluble and has a low molecular weight, which contributes to its pharmacokinetic properties. It does not require routine monitoring of anticoagulation levels, making it a convenient option for patients. Common side effects may include bleeding complications, but it is generally well-tolerated. Due to its specific mechanism of action and favorable safety profile, fondaparinux is a valuable therapeutic option in the management of thromboembolic disorders.
Formula:C31H53N3O49S8·10Na
InChI:InChI=1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1
InChI key:InChIKey=XNHJPDRIKNIMPQ-JASSWCPGSA-N
SMILES:O([C@H]1[C@H](OS(=O)(=O)O)[C@@H](NS(=O)(=O)O)[C@@H](O[C@@H]2[C@H](C(O)=O)O[C@@H](O[C@@H]3[C@@H](COS(=O)(=O)O)O[C@H](OC)[C@H](NS(=O)(=O)O)[C@H]3O)[C@H](OS(=O)(=O)O)[C@H]2O)O[C@@H]1COS(=O)(=O)O)[C@@H]4O[C@H](C(O)=O)[C@@H](O[C@@H]5[C@H](NS(=O)(=O)O)[C@@H](O)[C@H](O)[C@@H](COS(=O)(=O)O)O5)[C@H](O)[C@H]4O.[Na]
Synonyms:
  • IC 851589
  • SR 90107A
  • α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), sodium salt (1:10)
  • Fondaparinux sodium
  • α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), decasodium salt
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