CAS 114870-03-0

Fondaparinux

Description:

Fondaparinux is a synthetic anticoagulant that belongs to the class of drugs known as factor Xa inhibitors. It is primarily used for the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. Fondaparinux works by selectively inhibiting factor Xa, an essential component in the coagulation cascade, thereby preventing the formation of blood clots. The substance is characterized by its high bioavailability when administered subcutaneously and a long half-life, allowing for once-daily dosing. Fondaparinux is water-soluble and has a low molecular weight, which contributes to its pharmacokinetic properties. It does not require routine monitoring of anticoagulation levels, making it a convenient option for patients. Common side effects may include bleeding complications, but it is generally well-tolerated. Due to its specific mechanism of action and favorable safety profile, fondaparinux is a valuable therapeutic option in the management of thromboembolic disorders.

Formula: C₃₁H₅₃N₃O₄₉S₈·10Na

InChI: InChI=1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1

InChI key: InChIKey=XNHJPDRIKNIMPQ-JASSWCPGSA-N

SMILES: O([C@H]1[C@H](OS(=O)(=O)O)[C@@H](NS(=O)(=O)O)[C@@H](O[C@@H]2[C@H](C(O)=O)O[C@@H](O[C@@H]3[C@@H](COS(=O)(=O)O)O[C@H](OC)[C@H](NS(=O)(=O)O)[C@H]3O)[C@H](OS(=O)(=O)O)[C@H]2O)O[C@@H]1COS(=O)(=O)O)[C@@H]4O[C@H](C(O)=O)[C@@H](O[C@@H]5[C@H](NS(=O)(=O)O)[C@@H](O)[C@H](O)[C@@H](COS(=O)(=O)O)O5)[C@H](O)[C@H]4O.[Na]

Synonyms:

• IC 851589
• SR 90107A
• α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), sodium salt (1:10)
• Fondaparinux sodium
• α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), decasodium salt

Fondaparinux Sodium System Suitability Mixture B Solution

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Formula: C₃₁H₄₃N₃O₄₉S₈Na₁₀(majorcomponent)

Color and Shape: Colorless Liquid

Molecular weight: 1726.77078

Ref: 45-1282742

Fondaparinux Sodium Identification

CAS: 114870-03-0

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Color and Shape: White Off-White Powder

Molecular weight: 1726.77078

Ref: 45-1282718

Fondaparinux Sodium for Assay

CAS: 114870-03-0

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Formula: C₃₁H₄₃N₃O₄₉S₈Na₁₀

Color and Shape: Clear Colorless Liquid

Molecular weight: 1726.77078

Ref: 45-1282707

Fondaparinux Sodium System Suitability Mixture A Solution

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Formula: C₃₁H₄₃N₃O₄₉S₈Na₁₀(majorcomponent)

Color and Shape: Liquid

Molecular weight: 1726.77078

Ref: 45-1282731

Fondaparinux Sodium Salt

CAS: 114870-03-0

Formula: C₃₁H₄₃N₃O₄₉S₈·10Na

Color and Shape: White To Off-White Solid

Molecular weight: 1498.14 10*22.99

Ref: 4Z-F-711

Fondaparinux sodium salt

CAS: 114870-03-0

Formula: C₃₁H₄₃N₃O₄₉S₈·10Na

Molecular weight: 1728.08

Ref: 7W-GX8097

Fondaparinux Sodium Impurity 14

CAS: 114870-03-0

Formula: C₃₁H₄₂N₃NaO₅₂S₉·11Na

Color and Shape: White To Off-White Solid

Molecular weight: 1600.18 11*22.99

Ref: 4Z-F-7115

Fondaparinux sodium

CAS: 114870-03-0

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 1728.0815

Ref: IN-DA000FCU

Fondaparinux Sodium

Controlled Product

CAS: 114870-03-0

Applications Synthetic pentasaccharide corresponding to the anti-thrombin binding site of heparin. Anti-thrombotic.
References Herbert, J.M., et al.: Cardiovasc. Drug Rev., 15, 1 (1997), Turpie, A.G.G., et al.: Expert Opin. Drug Saf., 4, 707 (2005),

Formula: C₃₁H₄₃N₃O₄₉S₈·10Na

Color and Shape: Neat

Molecular weight: 1728.08

Ref: TR-F683500

Fondaparinux sodium

CAS: 114870-03-0

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 1728.082

Ref: TM-T4076

Fondaparinux sodium

CAS: 114870-03-0

(2S,3S,4R,5R,6R)-6-(((2R,3R,4R,5R,6R)-6-(((2R,3S,4S,5R,6R)-2-Carboxy-4-hydroxy-6-(((2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfoamino)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfooxy)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfoamino)-4-(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfoamino)-6-((sulfooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-carboxylic acid, decasodium salt

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Purity: 98%

Molecular weight: 1728.08

Ref: IN-DG168756

Fondaparinux sodium

CAS: 114870-03-0

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Molecular weight: 1728.1

Ref: BE-RMCF171001

FONDAPARINUX SODIUM

CAS: 114870-03-0

Purity: 98%

Molecular weight: 1728.030029

Ref: 10-F799841

Fondaparinux-dx Sodium

Controlled Product

CAS: 114870-03-0

Formula: C₃₁H₃₅D₉N₃Na₁₀O₄₉S₈

Color and Shape: Neat

Ref: TR-F683503

Fondaparinux Sodium System Suitability Mixture B

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Formula: C₃₁H₄₃N₃O₄₉S₈Na₁₀

Color and Shape: White Powder

Molecular weight: 1726.77078

Ref: 45-1282730

Fondaparinux sodium

CAS: 114870-03-0

Fondaparinux sodium is an anticoagulant, which is a synthetic pentasaccharide based on the antithrombin-binding sequence of heparin. As a meticulously engineered compound, it is derived by chemical synthesis. Its mode of action involves the selective inhibition of factor Xa, a critical enzyme in the coagulation cascade. By binding specifically to antithrombin III, it enhances the inactivation of factor Xa, thereby interrupting the pathway that leads to thrombin formation and ultimately preventing fibrin clot formation.

Formula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 1,728.09 g/mol

Ref: 3D-OF04094