CAS 1150310-15-8

Formula: C15H15N3O5

InChI: InChI=1S/C15H15N3O5/c16-9-11(15(21)17-4-2-1-3-5-17)6-10-7-12(18(22)23)14(20)13(19)8-10/h6-8,19-20H,1-5H2/b11-6+

InChI key: NVHDZUJODMCISU-IZZDOVSWSA-N

SMILES: C1CCN(CC1)C(=O)/C(=C/C2=CC(=C(C(=C2)O)O)[N+](=O)[O-])/C#N

Entacapone EP Impurity H

CAS: 1150310-15-8

Formula: C₁₅H₁₅N₃O₅

Color and Shape: Yellow Solid

Molecular weight: 317.30

Ref: 4Z-E-0312

(2E)-3-(3,4-Dihydroxy-5-nitrophenyl)-2-(piperidin-1-ylcarbonyl)prop-2-ennitrile

Controlled Product

CAS: 1150310-15-8

Formula: C₁₅H₁₅N₃O₅

Color and Shape: Neat

Molecular weight: 317.3

Ref: 86-MM1221.03

(alphaE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile

Controlled Product

CAS: 1150310-15-8

Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Formula: C₁₅H₁₅N₃O₅

Color and Shape: Neat

Molecular weight: 317.30

Ref: TR-D454135

(alphaE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile-d10

Controlled Product

CAS: 1150310-15-8

Formula: C₁₅D₁₀H₅N₃O₅

Color and Shape: Neat

Molecular weight: 327.358

Ref: TR-D454137

Entacapone EP impurity H

CAS: 1150310-15-8

Formula: C₁₅H₁₅N₃O₅

Molecular weight: 317.30

Ref: ST-EA-CP-E2008