CAS 115256-11-6
:Dofetilide
Description:
Dofetilide is a pharmaceutical compound primarily used as an antiarrhythmic agent for the treatment of atrial fibrillation and atrial flutter. It functions as a selective inhibitor of the rapid component of the delayed rectifier potassium current (IKr), which plays a crucial role in cardiac repolarization. Dofetilide is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, thereby helping to restore normal heart rhythm. The substance is typically administered orally and is known for its efficacy in maintaining sinus rhythm in patients with atrial fibrillation. However, it is associated with a risk of proarrhythmia, particularly in patients with renal impairment or those taking certain concomitant medications. Dofetilide is metabolized primarily by the kidneys, necessitating careful monitoring of renal function during treatment. Its chemical structure includes a bicyclic core, contributing to its pharmacological properties. As with any medication, it is essential to consider potential side effects and contraindications when prescribing dofetilide.
Formula:C19H27N3O5S2
InChI:InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChI key:InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N
SMILES:N(S(C)(=O)=O)C1=CC=C(CCN(CCOC2=CC=C(NS(C)(=O)=O)C=C2)C)C=C1
Synonyms:- Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
- N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
- N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methansulfonamid
- N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide
- Tikosyn
- Uk 68798
- Dofetilide
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
Dofetilide
CAS:Sulfonamides used as drugsFormula:C19H27N3O5S2Color and Shape:White Off-White Crystalline PowderMolecular weight:441.13921Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
CAS:Formula:C19H27N3O5S2Purity:98%Color and Shape:SolidMolecular weight:441.5648N-(4-(2-(Methyl(2-(4-(Methylsulfonamido)Phenoxy)Ethyl)Amino)Ethyl)Phenyl)Methanesulfonamide
CAS:N-(4-(2-(Methyl(2-(4-(Methylsulfonamido)Phenoxy)Ethyl)Amino)Ethyl)Phenyl)MethanesulfonamidePurity:99%Molecular weight:441.56g/molDofetilide
CAS:Formula:C19H27N3O5S2Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white powderMolecular weight:441.56Dofetilide
CAS:Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.Formula:C19H27N3O5S2Purity:97.85% - 99.06%Color and Shape:Off-White Or Yellowish Crystalline PowderMolecular weight:441.56Dofetilide
CAS:Controlled Product<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>Formula:C19H27N3O5S2Color and Shape:White Or BeigeMolecular weight:441.56Dofetilide
CAS:<p>Potassium channel blocker; antiarrhythmic agent</p>Formula:C19H27N3O5S2Purity:Min. 95%Color and Shape:PowderMolecular weight:441.57 g/molDofetilide - Bio-X ™
CAS:<p>Dofetilide belongs to the class of antiarrhythmic agents. It is a class III antiarrhythmic agent, which acts by blocking the potassium ion channels in the heart. It is used for the management of normal sinus rhythm and in atrial fibrillation. In vitro studies have shown that Dofetilide can prevent arrhythmias resulting from experimental models of congestive heart failure and can prevent re-entry mechanisms that lead to tachycardia.</p>Formula:C19H27N3O5S2Purity:Min. 95%Color and Shape:PowderMolecular weight:441.57 g/molDofetilide-13C
CAS:Controlled ProductFormula:CC18H27N3O5S2Color and Shape:NeatMolecular weight:442.557
![Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000GJ8.jpg&w=3840&q=75)
