CAS 115256-11-6: Dofetilide

Description: Dofetilide is a pharmaceutical compound primarily used as an antiarrhythmic agent for the treatment of atrial fibrillation and atrial flutter. It functions as a selective inhibitor of the rapid component of the delayed rectifier potassium current (IKr), which plays a crucial role in cardiac repolarization. Dofetilide is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, thereby helping to restore normal heart rhythm. The substance is typically administered orally and is known for its efficacy in maintaining sinus rhythm in patients with atrial fibrillation. However, it is associated with a risk of proarrhythmia, particularly in patients with renal impairment or those taking certain concomitant medications. Dofetilide is metabolized primarily by the kidneys, necessitating careful monitoring of renal function during treatment. Its chemical structure includes a bicyclic core, contributing to its pharmacological properties. As with any medication, it is essential to consider potential side effects and contraindications when prescribing dofetilide.

Formula: C₁₉H₂₇N₃O₅S₂

InChI: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

InChI key: InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N

SMILES: O=S(=O)(NC1=CC=C(OCCN(C)CCC2=CC=C(C=C2)NS(=O)(=O)C)C=C1)C

Synonyms:

• Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
• N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
• N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methansulfonamid
• N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide
• Tikosyn
• Uk 68798
• Dofetilide

Dofetilide

CAS: 115256-11-6

Sulfonamides used as drugs

• Formula: C₁₉H₂₇N₃O₅S₂
• Color and Shape: White Off-White Crystalline Powder
• Molecular weight: 441.13921

Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-

CAS: 115256-11-6

• Formula: C₁₉H₂₇N₃O₅S₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 441.5648

Dofetilide

CAS: 115256-11-6

• Formula: C₁₉H₂₇N₃O₅S₂
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 441.56

Dofetilide

CAS: 115256-11-6

• Formula: C₁₉H₂₇N₃O₅S₂
• Color and Shape: Off-White Solid
• Molecular weight: 441.56

N-(4-(2-(Methyl(2-(4-(Methylsulfonamido)Phenoxy)Ethyl)Amino)Ethyl)Phenyl)Methanesulfonamide

CAS: 115256-11-6

• Purity: 0.99
• Molecular weight: 441.56g/mol

Dofetilide

CAS: 115256-11-6

Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, …

• Formula: C₁₉H₂₇N₃O₅S₂
• Purity: 97.85% - 99.06%
• Color and Shape: Off-White Or Yellowish Crystalline Powder
• Molecular weight: 441.56

Dofetilide

CAS: 115256-11-6

Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug. References Carmeliet, D., et al.: J. …

• Formula: C₁₉H₂₇N₃O₅S₂
• Color and Shape: White Or Beige
• Molecular weight: 441.56

Dofetilide

CAS: 115256-11-6

Potassium channel blocker; antiarrhythmic agent

• Formula: C₁₉H₂₇N₃O₅S₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 441.57 g/mol

Dofetilide - Bio-X ™

CAS: 115256-11-6

Dofetilide belongs to the class of antiarrhythmic agents. It is a class III antiarrhythmic agent, …

• Formula: C₁₉H₂₇N₃O₅S₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 441.57 g/mol

Dofetilide-13C

CAS: 115256-11-6

• Formula: CC₁₈H₂₇N₃O₅S₂
• Color and Shape: Neat
• Molecular weight: 442.557