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CAS 115256-11-6

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Dofetilide

Description:
Dofetilide is a pharmaceutical compound primarily used as an antiarrhythmic agent for the treatment of atrial fibrillation and atrial flutter. It functions as a selective inhibitor of the rapid component of the delayed rectifier potassium current (IKr), which plays a crucial role in cardiac repolarization. Dofetilide is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, thereby helping to restore normal heart rhythm. The substance is typically administered orally and is known for its efficacy in maintaining sinus rhythm in patients with atrial fibrillation. However, it is associated with a risk of proarrhythmia, particularly in patients with renal impairment or those taking certain concomitant medications. Dofetilide is metabolized primarily by the kidneys, necessitating careful monitoring of renal function during treatment. Its chemical structure includes a bicyclic core, contributing to its pharmacological properties. As with any medication, it is essential to consider potential side effects and contraindications when prescribing dofetilide.
Formula:C19H27N3O5S2
InChI:InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChI key:InChIKey=IXTMWRCNAAVVAI-UHFFFAOYSA-N
SMILES:N(S(C)(=O)=O)C1=CC=C(CCN(CCOC2=CC=C(NS(C)(=O)=O)C=C2)C)C=C1
Synonyms:
  • Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
  • N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
  • N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methansulfonamid
  • N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide
  • Tikosyn
  • Uk 68798
  • Dofetilide
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