CAS 1154028-82-6

Molidustat

Description:

Molidustat is a small molecule drug primarily used in the treatment of anemia associated with chronic kidney disease (CKD). It functions as a hypoxia-inducible factor prolyl hydroxylase inhibitor, which enhances erythropoiesis by stabilizing hypoxia-inducible factors (HIFs) and subsequently promoting the production of erythropoietin (EPO). This mechanism mimics the physiological response to low oxygen levels, thereby stimulating red blood cell production. Molidustat is characterized by its ability to improve hemoglobin levels without the need for exogenous EPO administration. The substance is typically administered orally and has been studied for its efficacy and safety profile in various clinical trials. Its pharmacokinetics indicate a moderate half-life, allowing for once-daily dosing in patients. As with any medication, potential side effects may include hypertension and gastrointestinal disturbances, necessitating monitoring during treatment. Overall, Molidustat represents a novel therapeutic approach in managing anemia in CKD patients, providing an alternative to traditional therapies.

Formula: C₁₃H₁₄N₈O₂

InChI: InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2

InChI key: InChIKey=IJMBOKOTALXLKS-UHFFFAOYSA-N

SMILES: O=C1N(NC=C1N2C=CN=N2)C=3C=C(N=CN3)N4CCOCC4

Synonyms:

• BAY 85-3934
• 2-[6-(Morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
• 3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-
• Molidustat
• 1,2-Dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one

Molidustat

CAS: 1154028-82-6

Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。

Formula: C₁₃H₁₄N₈O₂

Purity: 98.79%

Color and Shape: Solid

Molecular weight: 314.3

Ref: TM-T2652

Molidustat (BAY85-3934)

CAS: 1154028-82-6

Formula: C₁₃H₁₄N₈O₂

Molecular weight: 314.31

Ref: 4Z-M-149001

Molidustat

Controlled Product

CAS: 1154028-82-6

Molidustat is a pharmaceutical agent designed as an oral hypoxia-inducible factor prolyl hydroxylase inhibitor. This compound is synthetically derived and functions by mimicking the body's response to low oxygen levels. Molidustat inhibits the prolyl hydroxylase enzymes, which regulate the degradation of hypoxia-inducible factors (HIF) under normal oxygen conditions. By preventing HIF degradation, molidustat leads to increased erythropoietin (EPO) production, stimulating red blood cell creation in the bone marrow.

Formula: C₁₃H₁₄N₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 314.3 g/mol

Ref: 3D-EWB02882

3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-

CAS: 1154028-82-6

Formula: C₁₃H₁₄N₈O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 314.3027

Ref: IN-DA000FY1