CAS 1156-19-0: Tolazamide

Description: Tolazamide is an oral hypoglycemic agent belonging to the class of sulfonylureas, primarily used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from pancreatic beta cells, thereby lowering blood glucose levels. The chemical formula of tolazamide is C11H13N3O3S, and it features a sulfonamide group, which is characteristic of its class. Tolazamide is typically administered in tablet form and is known for its moderate potency and duration of action compared to other sulfonylureas. Its pharmacokinetics involve absorption in the gastrointestinal tract, with metabolism occurring primarily in the liver. Common side effects may include hypoglycemia, gastrointestinal disturbances, and allergic reactions. Due to its mechanism of action, tolazamide may also have implications for weight management in diabetic patients. As with any medication, it is essential for patients to consult healthcare professionals for personalized advice and monitoring while using tolazamide.

Formula: C₁₄H₂₁N₃O₃S

InChI: InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)

InChI key: InChIKey=OUDSBRTVNLOZBN-UHFFFAOYSA-N

SMILES: O=C(NN1CCCCCC1)NS(=O)(=O)C2=CC=C(C=C2)C

Synonyms:

• 1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea
• 1-(Azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
• 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
• 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
• Benzenesulfonamide, N-[[(Hexahydro-1H-Azepin-1Yl)Amino]-Carbonyl]-4-Methyl-
• Diabewas
• N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea
• N-[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide
• Norglycin
• Nsc 70762
• Tolanase
• Tolazamid
• Tolazamida
• Tolazamide
• Tolinase
• U 17835
• Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-
• Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-
• 1-perhydroazepin-1-yl-3-tosylurea
• N-(azepan-1-ylcarbamoyl)-4-methylbenzenesulfonamide

Tolazamide

CAS: 1156-19-0

Sulfonamides used as drugs

• Formula: C₁₄H₂₁N₃O₃S
• Color and Shape: White Crystalline Powder
• Molecular weight: 311.13036

Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-

CAS: 1156-19-0

• Formula: C₁₄H₂₁N₃O₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 311.3998

Tolazamide

CAS: 1156-19-0

Tolazamide (U-17835) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of …

• Formula: C₁₄H₂₁N₃O₃S
• Purity: 100% - 99.7%
• Color and Shape: Solid
• Molecular weight: 311.4

N-(Azepan-1-Ylcarbamoyl)-4-Methylbenzenesulfonamide

CAS: 1156-19-0

• Purity: 98%
• Molecular weight: 311.40g/mol

Tolazamide

CAS: 1156-19-0

• Formula: C₁₄H₂₁N₃O₃S
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white powder
• Molecular weight: 311.40

Tolazamide

CAS: 1156-19-0

• Formula: C₁₄H₂₁N₃O₃S
• Color and Shape: Neat
• Molecular weight: 311.40

Tolazamide

CAS: 1156-19-0

• Formula: C₁₄H₂₁N₃O₃S
• Color and Shape: Neat
• Molecular weight: 311.40

Tolazamide

CAS: 1156-19-0

• Formula: C₁₄H₂₁N₃O₃S
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 311.40

Tolazamide

CAS: 1156-19-0

Applications Tolazamide is an antidiabetic. References Welling, et al.: J. Pharma. Sci., 71, 1259 (1982),

• Formula: C₁₄H₂₁N₃O₃S
• Color and Shape: White Crystalline Powder
• Molecular weight: 311.40

Tolazamide

CAS: 1156-19-0

Inhibitor of sulphonylurea receptor SUR1; hypoglycemic agent

• Formula: C₁₄H₂₁N₃O₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 311.4 g/mol