CAS 115956-12-2

Dolasetron

Description:

Dolasetron is a chemical compound primarily used as an antiemetic agent to prevent nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. It belongs to the class of 5-HT3 receptor antagonists, which work by blocking serotonin receptors in the central nervous system and gastrointestinal tract. Dolasetron is typically administered in its mesylate form, enhancing its solubility and bioavailability. The compound is characterized by its relatively low molecular weight and specific structural features that facilitate its interaction with serotonin receptors. It is usually available in both oral and intravenous formulations, allowing for flexible administration depending on patient needs. Common side effects may include headache, dizziness, and gastrointestinal disturbances, although it is generally well-tolerated. Dolasetron is metabolized in the liver, and its pharmacokinetics can be influenced by factors such as age and liver function. Overall, Dolasetron is an important therapeutic agent in managing chemotherapy-induced nausea and vomiting, contributing to improved patient comfort and quality of life during treatment.

Formula: C₁₉H₂₀N₂O₃

InChI: InChI=1/C19H20N2O3/c22-17-10-21-13-5-12(17)6-14(21)8-15(7-13)24-19(23)18-16-4-2-1-3-11(16)9-20-18/h1-4,12-15H,5-10H2

InChI key: InChIKey=UKTAZPQNNNJVKR-MMUVGSQPNA-N

SMILES: O(C(=O)C=1C=2C(NC1)=CC=CC2)[C@@H]3C[C@]4([N@]5[C@](CC(C4)C(=O)C5)(C3)[H])[H]

Synonyms:

• (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
• (6R)-3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2α,6α,8α,9aβ)-
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
• 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-isoindole-3-carboxylate
• Anemet
• Mdl 73147
• Dolasetron
• 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer
• Dolasteron
• Unii-82wi2L7Q6e
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
• Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
• rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
• Hsdb 7565
• dolasetron USP/EP/BP
• Dolasetronum [inn-latin]
• (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• Dolasetronum

1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 324.3737

Ref: IN-DA000H7X

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Molecular weight: 324.37

Ref: 7W-GP2323

Dolasetron

CAS: 115956-12-2

Dolasetron

Purity: ≥98%

Molecular weight: 324.37g/mol

Ref: 54-BUP13263

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Color and Shape: Off-White Solid

Molecular weight: 324.38

Ref: 4Z-D-097001

Dolasteron

CAS: 115956-12-2

Dolasteron

Purity: 98%

Molecular weight: 324.37g/mol

Ref: 54-OR1026379

Dolasetron-d4 (Indole-d4)

CAS: 115956-12-2

Formula: C₁₉H₁₆D₄N₂O₃

Color and Shape: Off-White Solid

Molecular weight: 328.40

Ref: 4Z-D-097012

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 324.38

Ref: 3B-D5820

Dolasetron

CAS: 115956-12-2

Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron is used to treat nausea and vomiting following chemotherapy.

Formula: C₁₉H₂₀N₂O₃

Purity: 99.84% - 99.86%

Color and Shape: White Powder

Molecular weight: 324.37

Ref: TM-T4568

Dolasetron

Controlled Product

CAS: 115956-12-2

Applications Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
References Boeijinga, P.H., et al.: Eur. J. Pharmacol., 219, 9 (1992), Miller, R.C., et al., Drug Dev. Res., 28, 87 (1993), Fauser, A.A., et al.: Eur. J. Cancer, 32, 1523 (1996), Graczyk, S.G., et al.: Anesth. Analg., 84, 325 (1997),

Formula: C₁₉H₂₀N₂O₃

Color and Shape: Neat

Molecular weight: 324.37

Ref: TR-D528500

Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester

CAS: 115956-12-2

Dolasetron mesylate is a mesylate of the biologically active form of dolasetron, which is an octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester. Dolasetron has been shown to be effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy or radiation therapy. It has been approved for use in adults with cancer who have not responded to other treatments. Dolasetron is rapidly absorbed from the gastrointestinal tract and is then distributed throughout the body, including into the brain. The elimination half life of dolasetron mesylate is about 2 hours and it binds to plasma proteins. Dolasetron mesylate specifically binds to serotonin receptors, which are found on cells in the gut. This binding inhibits serotonin induced contraction of bowel smooth muscle cells.

Formula: C₁₉H₂₀N₂O₃

Purity: Min. 95%

Color and Shape: White To Off-White To Grey Solid

Molecular weight: 324.37 g/mol

Ref: 3D-FD22592