CAS 115956-12-2: Dolasetron
Description:Dolasetron is a chemical compound primarily used as an antiemetic agent to prevent nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. It belongs to the class of 5-HT3 receptor antagonists, which work by blocking serotonin receptors in the central nervous system and gastrointestinal tract. Dolasetron is typically administered in its mesylate form, enhancing its solubility and bioavailability. The compound is characterized by its relatively low molecular weight and specific structural features that facilitate its interaction with serotonin receptors. It is usually available in both oral and intravenous formulations, allowing for flexible administration depending on patient needs. Common side effects may include headache, dizziness, and gastrointestinal disturbances, although it is generally well-tolerated. Dolasetron is metabolized in the liver, and its pharmacokinetics can be influenced by factors such as age and liver function. Overall, Dolasetron is an important therapeutic agent in managing chemotherapy-induced nausea and vomiting, contributing to improved patient comfort and quality of life during treatment.
Formula:C19H20N2O3
InChI:InChI=1/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13+,14+
InChI key:InChIKey=UKTAZPQNNNJVKR-MMUVGSQPNA-N
SMILES:O=C(OC1CC2N3CC(=O)C(C2)CC3C1)C4=CNC=5C=CC=CC54
- Synonyms:
- (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
- (6R)-3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
- 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2α,6α,8α,9aβ)-
- 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
- 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
- 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.
- 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
- 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-isoindole-3-carboxylate
- Anemet
- Mdl 73147
- See more synonyms
- Dolasetron
