CAS 115956-12-2

Dolasetron

Description:

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT 3 (K i = 20 nM). 1 It is selective for 5-HT 3 receptors over 5-HT 1A , 5-HT 1B , 5-HT 2 , dopamine D 2 , α 1 -, α 2 -, β-adrenergic, M 1-5 muscarinic acetylcholine, and neurokinin-1 (NK 1 ) receptors (IC 50 s = >10 μM for all). 2 Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC 50 = 3.8 nM). 1 It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin (Item No. 13119 ) in ferrets when administered at doses of 0.5 or 2 mg/kg. 2 Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

Formula: C₁₉H₂₀N₂O₃

InChI: InChI=1/C19H20N2O3/c22-17-10-21-13-5-12(17)6-14(21)8-15(7-13)24-19(23)18-16-4-2-1-3-11(16)9-20-18/h1-4,12-15H,5-10H2

InChI key: InChIKey=UKTAZPQNNNJVKR-MMUVGSQPNA-N

SMILES: O(C(=O)C=1C=2C(NC1)=CC=CC2)[C@@H]3C[C@]4([N@]5[C@](CC(C4)C(=O)C5)(C3)[H])[H]

Synonyms:

• (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
• (6R)-3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2α,6α,8α,9aβ)-
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
• 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-isoindole-3-carboxylate
• Anemet
• Mdl 73147
• Dolasetron
• 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer
• Dolasteron
• Unii-82wi2L7Q6e
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
• Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
• rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
• Hsdb 7565
• dolasetron USP/EP/BP
• Dolasetronum [inn-latin]
• (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• Dolasetronum

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 324.38

Ref: 3B-D5820

Dolasteron

CAS: 115956-12-2

Dolasteron

Formula: C₁₉H₂₀N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 324.37

Ref: 54-OR1026379

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Color and Shape: Off-White Solid

Molecular weight: 324.38

Ref: 4Z-D-097001

Dolasetron

CAS: 115956-12-2

Dolasetron

Formula: C₁₉H₂₀N₂O₃

Purity: ≥98%

Molecular weight: 324.37

Ref: 54-BUP13263

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Molecular weight: 324.37

Ref: 7W-GP2323

Dolasetron-d4 (Indole-d4)

CAS: 115956-12-2

Formula: C₁₉H₁₆D₄N₂O₃

Color and Shape: Off-White Solid

Molecular weight: 328.40

Ref: 4Z-D-097012

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 324.3737

Ref: IN-DA000H7X

Dolasetron

Controlled Product

CAS: 115956-12-2

Applications Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
References Boeijinga, P.H., et al.: Eur. J. Pharmacol., 219, 9 (1992), Miller, R.C., et al., Drug Dev. Res., 28, 87 (1993), Fauser, A.A., et al.: Eur. J. Cancer, 32, 1523 (1996), Graczyk, S.G., et al.: Anesth. Analg., 84, 325 (1997),

Formula: C₁₉H₂₀N₂O₃

Color and Shape: Neat

Molecular weight: 324.37

Ref: TR-D528500

Dolasetron

CAS: 115956-12-2

Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron is used to treat nausea and vomiting following chemotherapy.

Formula: C₁₉H₂₀N₂O₃

Purity: 99.84% - 99.86%

Color and Shape: Solid

Molecular weight: 324.3737

Ref: TM-T4568

Dolasetron

CAS: 115956-12-2

rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate

Formula: C₁₉H₂₀N₂O₃

Purity: 98%

Molecular weight: 324.37

Ref: IN-DG235697

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Molecular weight: 324.4

Ref: BE-RMCD210000

Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester

CAS: 115956-12-2

Dolasetron mesylate is a mesylate of the biologically active form of dolasetron, which is an octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester. Dolasetron has been shown to be effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy or radiation therapy. It has been approved for use in adults with cancer who have not responded to other treatments. Dolasetron is rapidly absorbed from the gastrointestinal tract and is then distributed throughout the body, including into the brain. The elimination half life of dolasetron mesylate is about 2 hours and it binds to plasma proteins. Dolasetron mesylate specifically binds to serotonin receptors, which are found on cells in the gut. This binding inhibits serotonin induced contraction of bowel smooth muscle cells.

Formula: C₁₉H₂₀N₂O₃

Purity: Min. 95%

Color and Shape: White To Off-White To Grey Solid

Molecular weight: 324.37 g/mol

Ref: 3D-FD22592

Dolasetron

CAS: 115956-12-2

Formula: C₁₉H₂₀N₂O₃

Molecular weight: 324.38

Ref: ST-EA-CP-D39000