CAS 1163-36-6

Clemizole hydrochloride

Description:

Clemizole hydrochloride is a synthetic compound primarily recognized for its antihistaminic properties. It belongs to the class of diphenylmethylpiperazines and is often utilized in the treatment of allergic conditions. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. Its mechanism of action involves antagonism of histamine H1 receptors, which helps alleviate symptoms associated with allergic reactions. Additionally, Clemizole has been studied for its potential neuroprotective effects and its ability to modulate certain neurotransmitter systems. However, it is essential to note that while it has therapeutic applications, the use of Clemizole hydrochloride may be accompanied by side effects, including sedation and anticholinergic effects. As with any medication, proper dosage and monitoring are crucial to minimize adverse reactions. Overall, Clemizole hydrochloride is a noteworthy compound in the realm of antihistamines, with a unique profile that warrants further investigation in clinical settings.

Formula: C₁₉H₂₀ClN₃·ClH

InChI: InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H

InChI key: InChIKey=DNFMJYXRIMLMBZ-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1CN3CCCC3)=CC=CC2)C4=CC=C(Cl)C=C4.Cl

Synonyms:

• 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole hydrochloride
• 1-(4-Chlorobenzyl)-2-(pyrrolidinylmethyl)-1,3-benzimidazole hydrochloride
• 1-[4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, Monohydrochloride
• 1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride
• 1-p-Chlorobenzyl-2-pyrrolidylmethyl benzimidazole hydrochloride
• 1-{[1-(4-chlorobenzyl)-1H-benzimidazol-2-yl]methyl}pyrrolidinium chloride
• 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1)
• 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride
• Al 20
• Allercur
• Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-, monohydrochloride
• Histacuran
• Klemidox

Clemizole Hydrochloride

CAS: 1163-36-6, 442-52-4

Formula: C₁₉H₂₀ClN₃·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 362.30

Ref: 3B-C3468

1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1)

CAS: 1163-36-6

Formula: C₁₉H₂₁Cl₂N₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 362.2961

Ref: IN-DA000C5Q

Clemizole hydrochloride

CAS: 1163-36-6

Formula: C₁₉H₂₀ClN₃

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 325.84

Ref: 7W-GP7755

Clemizole hydrochloride

CAS: 1163-36-6

Clemizole hydrochloride blocks H1 histamine receptors and inhibits HCV replication and NS4B RNA binding.

Formula: C₁₉H₂₁Cl₂N₃

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 362.3

Ref: TM-T1822L

Clemizole HCl

CAS: 1163-36-6

Formula: C₁₉H₂₀ClN₃·HCl

Molecular weight: 325.84 36.46

Ref: 4Z-C-270001

Clemizole hydrochloride

Controlled Product

CAS: 1163-36-6

Inhibits TRPC5 channel blocker; histamine (H1) receptor antagonist

Formula: C₁₉H₂₀ClN₃·HCl

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 362.3

Ref: 3D-FC64983

Clemizole Hydrochloride

Controlled Product

CAS: 1163-36-6

Applications Clemizole Hydrochloride inhibits Hepatitis C RNA replication in cell culture through the suppression of the binding between the nonstructural protein 4B and the viral RNA genome with little toxicity for the host cell. Clemizole Hydrochloride is also a potent inhibitor of transient receptor potential channel TRPC5.
References Einav, S., et al.: Nat. Biotechnol., 26, 1019 (2008); Richter, J. M., et al.: Mol. Pharmacol., 86, 514 (2014)

Formula: C₁₉H₂₀ClN₃·ClH

Color and Shape: Neat

Molecular weight: 362.30

Ref: TR-C559740

Clemizole Hydrochloride

CAS: 1163-36-6

Color and Shape: Neat

Ref: 61-FOR1965.00