CAS 116313-94-1: Nitecapone

Description: Nitecapone is a chemical compound primarily recognized for its role as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines. This compound is often studied in the context of neurological disorders, particularly Parkinson's disease, where it may enhance the efficacy of dopaminergic therapies by prolonging the action of levodopa. Nitecapone is characterized by its specific molecular structure, which includes functional groups that facilitate its interaction with the COMT enzyme. The compound is typically administered in a pharmaceutical context, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic potential and safety profile. As with many pharmacological agents, understanding its side effects, interactions with other medications, and optimal dosing regimens is essential for effective clinical use. Overall, Nitecapone represents a significant area of research in the development of treatments for conditions associated with dopamine dysregulation.

Formula: C₁₂H₁₁NO₆

InChI: InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3

InChI key: InChIKey=UPMRZALMHVUCIN-UHFFFAOYSA-N

SMILES: O=C(C(=CC=1C=C(O)C(O)=C(C1)N(=O)=O)C(=O)C)C

Synonyms:

• 2,4-Pentanedione, 3-((3,4-dihydroxy-5-nitrophenyl)methylene)-
• 3-((3,4-Dihydroxy-5-nitrophenyl)methylene)-2,4-pentanedione
• 3-(3,4-Dihydroxy-5-nitrobenzylidene)-2,4-pentanedione
• 3-[(3,4-Dihydroxy-5-Nitrophenyl)Methylidene]Pentane-2,4-Dione
• Brn 6420063
• Nitecapona
• Nitecapona [INN-Spanish]
• Nitecapone [INN]
• Nitecaponum
• Nitecaponum [INN-Latin]
• Or 462
• Unii-98Bs722498
• Nitecapone

2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-

CAS: 116313-94-1

• Formula: C₁₂H₁₁NO₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 265.2188

Nitecapone

CAS: 116313-94-1

• Formula: C₁₂H₁₁NO₆
• Molecular weight: 265.22

"3-(3,4-Dihydroxy-5-Nitrobenzylidene)Pentane-2,4-Dione"

CAS: 116313-94-1

• Purity: 98%
• Molecular weight: 265.22g/mol

Nitecapone

CAS: 116313-94-1

Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)

• Formula: C₁₂H₁₁NO₆
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 265.22

Nitecapone

CAS: 116313-94-1

Applications Inhibitor for the treatment of Parkinson's disease. Not a dangerous good if item is …

• Formula: C₁₂H₁₁NO₆
• Color and Shape: Neat
• Molecular weight: 265.22

Nitecapone

CAS: 116313-94-1

Nitecapone is a drug that has been used to treat Parkinson's disease and bowel diseases. …

• Formula: C₁₂H₁₁NO₆
• Purity: Min. 95%
• Molecular weight: 265.22 g/mol