CAS 116649-85-5: Ramatroban

Description: Ramatroban is a chemical compound classified as a selective thromboxane A2 receptor antagonist. It is primarily known for its potential therapeutic applications, particularly in the treatment of conditions such as asthma and allergic rhinitis. The molecular structure of Ramatroban features a complex arrangement that includes a carboxylic acid group, contributing to its biological activity. It exhibits anti-inflammatory properties by inhibiting the action of thromboxane A2, a potent vasoconstrictor and platelet aggregator. Ramatroban is typically administered in oral form and has been studied for its effects on bronchial hyperreactivity and other allergic responses. Its pharmacokinetics indicate a moderate absorption profile, with metabolism occurring primarily in the liver. The compound is generally well-tolerated, with a safety profile that has been evaluated in clinical studies. Overall, Ramatroban represents a significant interest in pharmacology due to its targeted action on specific receptors involved in inflammatory processes.

Formula: C₂₁H₂₁FN₂O₄S

InChI: InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1

InChI key: InChIKey=LDXDSHIEDAPSSA-OAHLLOKOSA-N

SMILES: O=C(O)CCN1C=2C=CC=CC2C3=C1CCC(NS(=O)(=O)C4=CC=C(F)C=C4)C3

Synonyms:

• (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
• 3-[(3R)-3-[(4-Fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
• 3-[(3R)-3-{[(4-fluorophenyl)sulfonyl]amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl]propanoic acid
• 3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
• 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-
• 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)-
• BAY-u 3405
• Baynas
• Ramatroban

Ramatroban

CAS: 116649-85-5

Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.

• Formula: C₂₁H₂₁FN₂O₄S
• Purity: 98.12% - 99.96%
• Color and Shape: Crystalline Solid
• Molecular weight: 416.47

9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-

CAS: 116649-85-5

• Formula: C₂₁H₂₁FN₂O₄S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 416.4658

Ramatroban

CAS: 116649-85-5

• Formula: C₂₁H₂₁FN₂O₄S
• Molecular weight: 416.47

Ramatroban-d4

CAS: 116649-85-5

• Formula: C₂₁H₁₇D₄FN₂O₄S
• Color and Shape: White To Off-White Solid
• Molecular weight: 420.49

Ramatroban

CAS: 116649-85-5

• Formula: C₂₁H₂₁FN₂O₄S
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 416.47

Ramatroban

CAS: 116649-85-5

• Formula: C₂₁H₂₁FN₂O₄S
• Molecular weight: 416.47

Ramatroban

CAS: 116649-85-5

Dual inhibitor of thromboxane receptor and DP2 postanoid receptor

• Formula: C₂₁H₂₁FN₂O₄S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 416.47 g/mol

Ramatroban

CAS: 116649-85-5

Applications A thromboxane receptor antagonist for use in the treatment of coronary artery disease. References …

• Formula: C₂₁H₂₁FN₂O₄S
• Color and Shape: Neat
• Molecular weight: 416.47