CAS 1173699-31-4

Formula: C23H22FN7O3

InChI: InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1

InChI key: DWHXUGDWKAIASB-CQSZACIVSA-N

SMILES: C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC

6-[(1R)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one

CAS: 1173699-31-4

Formula: C₂₃H₂₂FN₇O₃

Purity: %

Color and Shape: Solid

Molecular weight: 463.4643

Ref: IN-DA000E62

(R)-6-(1-(8-Fluoro-6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl)Ethyl)-3-(2-Methoxyethoxy)-1,6-Naphthyridin-5(6H)-One

CAS: 1173699-31-4

(R)-6-(1-(8-Fluoro-6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl)Ethyl)-3-(2-Methoxyethoxy)-1,6-Naphthyridin-5(6H)-One

Formula: C₂₃H₂₂FN₇O₃

Purity: 98+%

Molecular weight: 463.46

Ref: 54-PC108757

AMG-337

CAS: 1173699-31-4

AMG-337

Formula: C₂₃H₂₂FN₇O₃

Purity: ≥98%

Molecular weight: 463.46

Ref: 54-BUP08211

AMG-337

CAS: 1173699-31-4

AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337 inhibits MET kinase activity (IC50: < 5 nM).

Formula: C₂₃H₂₂FN₇O₃

Purity: 99.26% - 99.9%

Color and Shape: White Solid

Molecular weight: 463.46

Ref: TM-T3209

AMG-337

CAS: 1173699-31-4

(R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one

Formula: C₂₃H₂₂FN₇O₃

Purity: 98+%

Molecular weight: 463.46

Ref: IN-DG629948

AMG 337

Controlled Product

CAS: 1173699-31-4

Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.
References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);

Formula: C₂₃H₂₂FN₇O₃

Color and Shape: Neat

Molecular weight: 463.46

Ref: TR-A576575

AMG 337

CAS: 1173699-31-4

AMG 337 is a small molecule inhibitor, which is derived from synthetic chemical processes, with a mode of action involving the selective inhibition of the c-Met receptor tyrosine kinase. The c-Met receptor, also known as hepatocyte growth factor receptor, plays a critical role in various cellular processes such as proliferation, survival, and motility. Dysregulation of c-Met signaling is implicated in several types of cancers, making it a significant therapeutic target.

Formula: C₂₃H₂₂FN₇O₃

Purity: Min. 95%

Molecular weight: 463.46 g/mol

Ref: 3D-YWB69931