CAS 117399-93-6

endothelin 3

Description:

Endothelin-3 (ET-3) is a potent vasoconstrictor peptide that plays a significant role in various physiological processes, including vascular homeostasis and regulation of blood pressure. It is part of the endothelin family, which consists of three isoforms: endothelin-1, endothelin-2, and endothelin-3. ET-3 is primarily produced by endothelial cells and has a high affinity for endothelin receptors, particularly the ETA and ETB receptors, which are G protein-coupled receptors. This peptide is composed of 21 amino acids and is characterized by its ability to induce smooth muscle contraction and influence cell proliferation. In addition to its cardiovascular effects, endothelin-3 is involved in the regulation of renal function and has implications in various pathological conditions, including hypertension and heart failure. Its synthesis and release can be influenced by various factors, including hypoxia and inflammatory cytokines. Overall, endothelin-3 is a critical mediator in the endothelin signaling pathway, with diverse biological effects across different tissues.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Synonyms:

• Endothelin-3,Human
• H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Oh
• Endothelin-3 (Human, Mouse, Rabbit, Rat)
• Endothelin-3 (Human) (Porcine, Rat, Rabbit)
• Endothelin-3 (Human, Rat, Pig)
• Endothelin-3 (Human, Rat, Porcine, Rabbit)
• Endothelin 3, human, rat, ≥97% (HPLC), powder
• Human endothelin-3
• 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.
• Endothelin 3 (Rat,Human)
• CTCFTYKDKECVYYCHLDIIW
• CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
• Endothelin 3【rabbit】
• Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
• et-3
• Anti-EDN3 antibody produced in rabbit
• CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP
• human,rat
• ET-3 (huMan, Mouse, rabbit, rat)
• H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
• Endothelin 3 (huMan)(9CI)
• Endothelin 3 (mouse intestine)
• ET-3 (HUMAN, MOUSE, RABBIT, RAT)
• CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
• ENDOTHELIN-3
• Rat endothelin-3
• ENDOTHELIN-III, HUMAN, RAT
• Endothelin 3 huMan, ratEndothelin
• ENDOTHELIN 3 HUMAN, RAT
• L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)
• ANTI-EDN3 (C-TERM) antibody produced in rabbit
• Endothelin 3【rat】
• ENDOTHELIN 3, HUMAN, RAT, 50 UG*
• ET-3 (HUMAN, RAT)
• ET-3 (HUMAN, RAT, PIG)
• M.W. 2643.04 C121H168N26O33S4
• Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
• CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT
• EDN3
• Endothelin 3【canine】
• ET-3, HUMAN AND RAT
• CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
• 19: PN: WO2007112069 SEQID: 10 claimed protein
• ET-3, HUMAN
• ENDOTHELIN 3, HUMAN AND RAT
• H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)

Endothelin-3, Human

CAS: 117399-93-6

For cellular and molecular biology applications

Color and Shape: White to off-white, Lyophilized Powder

Ref: 02-J66312

Endothelin-3, human, mouse, rabbit, rat

CAS: 117399-93-6

Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 2643.04

Ref: TM-TP1175

Endothelin-3 (human, mouse, rabbit, rat) acetate

CAS: 117399-93-6

Acetate salt

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄•(C₂H₄O₂)x

Purity: Min. 95%

Molecular weight: 2,643.05 g/mol

Ref: 3D-FE110371

(3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -carboxyethyl)-10-(carboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21,

CAS: 117399-93-6

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Molecular weight: 2,643.1 g/mol

Ref: 3D-PP50516

Endothelin 3, human, rat

CAS: 117399-93-6

Custom research peptide; min purity 95%.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: Min. 95%

Molecular weight: 2,643.1 g/mol

Ref: 3D-PE16957

Endothelin-3 (Human)

CAS: 117399-93-6

Endothelin-3 (ET-3) is a protein that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys and Cys3-Cys11, is sourced from Porcine, Rat and Rabbit and is available as a 0.5mg vial

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: Min. 95%

Molecular weight: 2,643 g/mol

Ref: 3D-PED-4199-V

Endothelin-3 (Human)

CAS: 117399-93-6

Endothelin-3 (ET-3) is a protein that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys and Cys3-Cys11, is sourced from Porcine, Rat and Rabbit and is available as a 0.1mg vial. It can be use as a research tool for studying the function of endothelin receptors.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: Min. 95%

Molecular weight: 2,643 g/mol

Ref: 3D-PED-4199-S

Endothelin-3 (human, mouse, rabbit, rat) trifluoroacetate salt

CAS: 117399-93-6

Trifluoroacetate salt

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: Min. 95%

Molecular weight: 2,643.05 g/mol

Ref: 3D-FE110256

Endothelin-3 (human, mouse, rabbit, rat)

CAS: 117399-93-6

ET-1, ET-2, and ET-3 are the products of three distinct endothelin genes. ET-2 and ET-3 are similar to ET-1, but differ in two and six amino acids, respectively. All three isopeptides produce strong in vitro vasoconstrictor and in vivo pressor responses. However, the quantitative profiles of their pharmacological activities vary greatly.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: 93.7%

Color and Shape: White Lyophilisate

Molecular weight: 2643.08

Ref: 01-4013291

Endothelin-3 (human, mouse, rabbit, rat)

CAS: 117399-93-6

Potent constrictor of rat blood vessels in vitro and an effective pressor agent in vivo. Endothelin-3 (ET-3) has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. ET-3 displays selectivity for the ETC receptor.

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: 95.0%

Color and Shape: White

Molecular weight: 2643.08

Ref: 01-4095915

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

CAS: 117399-93-6

Formula: C₁₂₁H₁₆₈N₂₆O₃₃S₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 2643.0430

Ref: IN-DA008RJ5