CAS 117399-94-7
:endothelin 1
Description:
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide that plays a crucial role in various physiological and pathological processes, particularly in the cardiovascular system. It is a 21-amino acid peptide produced primarily by endothelial cells and is involved in regulating blood pressure, vascular tone, and fluid balance. ET-1 is known for its ability to induce smooth muscle contraction and promote cell proliferation, making it significant in conditions such as hypertension and heart failure. The peptide exerts its effects through specific receptors, primarily endothelin receptor type A (ETA) and type B (ETB), which are distributed throughout the body. In addition to its cardiovascular effects, endothelin-1 is implicated in various other biological processes, including inflammation, cell growth, and neurobiology. Due to its potent effects, ET-1 is a target for therapeutic interventions in diseases characterized by excessive vasoconstriction and tissue remodeling. Its CAS number, 117399-94-7, is used for identification in chemical databases and regulatory contexts.
Formula:C109H159N25O32S5
InChI:InChI=1/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)
SMILES:CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)CC)N=C(C(CC(=O)O)N=C(C(CC(C)C)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(CO)C(=NC2CSSCC(C(=NC(C(C)C)C(=NC(Cc3ccc(cc3)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCCCN)N=C(C(CC(=O)O)N=C(C(CCSC)N=C(C(CC(C)C)N=C(C(CO)N=C(C(CO)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O
Synonyms:- Endothelin 1 human, porcine
- H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
- Endothelin 1, Human and Porcine
- Endothelin-1,Human
- Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt
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Found 8 products.
Endothelin-1 (human, bovine, dog, mouse, porcine, rat)
CAS:Endothelin-1 (ET-1) is a potent vasoconstrictive 21-amino acid peptide produced by endothelia cells. It acts on endothelia cells and on the underlying smooth muscle cells as a modulator of vascular tone. ET-1 shows selectivity for the ET-A receptor.Formula:C109H159N25O32S5Purity:95.0%Color and Shape:WhiteMolecular weight:2491.94Endothelin-1 (human, bovine, dog, mouse, porcine, rat)
CAS:Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.Formula:C109H159N25O32S5Purity:91.90%Color and Shape:WhiteMolecular weight:2491.94Endothelin-1 Acetate
CAS:Formula:C109H159N25O32S5Purity:95%~99%Color and Shape:White to Off-white PowderMolecular weight:2491.9Endothelin 1 (swine, human)
CAS:<p>Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.</p>Formula:C109H159N25O32S5Color and Shape:White PowderMolecular weight:2491.9Endothelin-1 (Human)
CAS:<p>Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.1mg vial.</p>Formula:C109H159N25O32S5Purity:Min. 95%Molecular weight:2,491.9 g/molEndothelin-1 (Human)
CAS:<p>Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.<br>This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.5mg vial.</p>Formula:C109H159N25O32S5Purity:Min. 95%Molecular weight:2,491.9 g/molEndothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate
CAS:<p>Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.</p>Formula:C109H159N25O32S5•(C2H4O2)xPurity:Min. 95%Molecular weight:2,491.91 g/mol
