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CAS 1174161-69-3

:

BMS817378

Description:
BMS-817378, with the CAS number 1174161-69-3, is a chemical compound that has been investigated primarily for its potential therapeutic applications, particularly in the field of oncology. It is classified as a small molecule inhibitor, specifically targeting certain pathways involved in cancer cell proliferation and survival. The compound exhibits selectivity for specific protein kinases, which play crucial roles in signaling pathways that regulate cell growth and division. BMS-817378 has shown promise in preclinical studies, demonstrating efficacy against various cancer types by inducing apoptosis in malignant cells. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its suitability for clinical use. Additionally, ongoing research aims to elucidate its mechanism of action, potential side effects, and optimal dosing regimens. As with many investigational drugs, further studies are necessary to fully understand its therapeutic potential and safety profile in humans.
Formula:C24H18ClF2N4O7P
InChI:InChI=1S/C24H18ClF2N4O7P/c25-21-20(7-8-29-23(21)28)38-19-6-5-15(9-18(19)27)30-24(33)17-11-31(12-37-39(34,35)36)10-16(22(17)32)13-1-3-14(26)4-2-13/h1-11H,12H2,(H2,28,29)(H,30,33)(H2,34,35,36)
InChI key:KXDZWUPUSDCGDD-UHFFFAOYSA-N
SMILES:C1=CC(=CC=C1C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)COP(=O)(O)O)F
Synonyms:
  • [3-[[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxo-4H-pyridin-1-yl]methyl dihydrogen phosphate
  • 3(4H)-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1-[(phosphonooxy)methyl]-
  • N-?[4-?[(2-?amino-?3-?chloro-?4-?pyridinyl)?oxy]?-?3-?fluorophenyl]?-?5-?(4-?fluorophenyl)?-?4-
  • KXDZWUPUSDCGDD-UHFFFAOYSA-N
  • BMS-817378;BMS817378;BMS 817378
  • N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1-[(phosphonooxy)methyl]-3(4H)-pyridinecarboxamide
  • BMS817378
  • (3-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenylcarbamoyl)-5-(4-fluorophenyl)-4-oxopyridin-1(4H)-yl)methyl dihydrogen phosphate
  • BMS817378; BMS 817378
  • BMS-817378Potent
  • See more synonyms
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