CAS 1178583-17-9

7-[4-[Bis(2-hydroxyethyl)amino]butoxy]-5-hydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one

Formula: C₂₄H₂₉NO₇

InChI: InChI=1S/C24H29NO7/c1-30-23-21(31-14-6-5-9-25(10-12-26)11-13-27)16-19(29)22-18(28)15-20(32-24(22)23)17-7-3-2-4-8-17/h2-4,7-8,15-16,26-27,29H,5-6,9-14H2,1H3

InChI key: QWQDULIQJQIEKB-UHFFFAOYSA-N

SMILES: COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)OCCCCN(CCO)CCO

Synonyms:

• 7-[4-[Bis(2-hydroxyethyl)amino]butoxy]-5-hydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
• PERK/eIF2α activator 1

PERK/eIF2α activator 1

CAS: 1178583-17-9

Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].

Formula: C₂₄H₂₉NO₇

Color and Shape: Solid

Molecular weight: 443.49

Ref: TM-T87131