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CAS 117924-33-1

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di-tert-butyl N,N-diethylphosphor-amidite

Description:
Di-tert-butyl N,N-diethylphosphor-amidite is a chemical compound characterized by its phosphoramidite structure, which is commonly used in organic synthesis, particularly in the field of oligonucleotide chemistry. This compound features two tert-butyl groups and two ethyl groups attached to a phosphorus atom, contributing to its steric bulk and solubility properties. It is typically a colorless to pale yellow liquid, exhibiting moderate volatility. The presence of the phosphoramidite functional group makes it a valuable reagent for the phosphorylation of nucleosides and nucleotides, facilitating the synthesis of DNA and RNA sequences. Its reactivity is influenced by the electron-donating nature of the alkyl groups, which stabilize the phosphorus center. Additionally, di-tert-butyl N,N-diethylphosphor-amidite is sensitive to moisture and should be handled under anhydrous conditions to prevent hydrolysis. Safety precautions are necessary when working with this compound, as it may pose health risks if inhaled or ingested. Overall, its unique structure and reactivity make it an important tool in synthetic organic chemistry.
Formula:C12H28NO2P
InChI:InChI=1/C12H28NO2P/c1-9-13(10-2)16(14-11(3,4)5)15-12(6,7)8/h9-10H2,1-8H3
SMILES:CCN(CC)P(OC(C)(C)C)OC(C)(C)C
Synonyms:
  • Di-tert-butyl N,N-diethylphosphoramidite
  • Di-t-butyl N,N-diethylphosphoramidite
  • Di-Tert-Butyl Diethylamidophosphite
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