CAS 117924-33-1

di-tert-butyl N,N-diethylphosphor-amidite

Description:

Di-tert-butyl N,N-diethylphosphor-amidite is a chemical compound characterized by its phosphoramidite structure, which is commonly used in organic synthesis, particularly in the field of oligonucleotide chemistry. This compound features two tert-butyl groups and two ethyl groups attached to a phosphorus atom, contributing to its steric bulk and solubility properties. It is typically a colorless to pale yellow liquid, exhibiting moderate volatility. The presence of the phosphoramidite functional group makes it a valuable reagent for the phosphorylation of nucleosides and nucleotides, facilitating the synthesis of DNA and RNA sequences. Its reactivity is influenced by the electron-donating nature of the alkyl groups, which stabilize the phosphorus center. Additionally, di-tert-butyl N,N-diethylphosphor-amidite is sensitive to moisture and should be handled under anhydrous conditions to prevent hydrolysis. Safety precautions are necessary when working with this compound, as it may pose health risks if inhaled or ingested. Overall, its unique structure and reactivity make it an important tool in synthetic organic chemistry.

Formula: C₁₂H₂₈NO₂P

InChI: InChI=1/C12H28NO2P/c1-9-13(10-2)16(14-11(3,4)5)15-12(6,7)8/h9-10H2,1-8H3

SMILES: CCN(CC)P(OC(C)(C)C)OC(C)(C)C

Synonyms:

• Di-tert-butyl N,N-diethylphosphoramidite
• Di-t-butyl N,N-diethylphosphoramidite
• Di-Tert-Butyl Diethylamidophosphite

Di-Tert-Butyl Diethylphosphoramidite

CAS: 117924-33-1

Di-Tert-Butyl Diethylphosphoramidite

Formula: C₁₂H₂₈NO₂P

Purity: 98%

Molecular weight: 249.33

Ref: 54-OR1013009

Di-tert-butyl N,N-diethylphosphoramidite

CAS: 117924-33-1

Formula: C₁₂H₂₈NO₂P

Purity: 98%

Color and Shape: Liquid

Molecular weight: 249.3300

Ref: IN-DA0034SB

Di-tert-butyl Diethylphosphoramidite

CAS: 117924-33-1

Formula: C₁₂H₂₈NO₂P

Purity: >95.0%(GC)(qNMR)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 249.33

Ref: 3B-D4252

Di-tert-butyl diethylphosphoramidite

CAS: 117924-33-1

Formula: C₁₂H₂₈NO₂P

Purity: 98%

Color and Shape: Liquid

Molecular weight: 249.335

Ref: 10-F463053

Di-t-butyl N,N-Diethylphosphoramidite (~90%)

Controlled Product

CAS: 117924-33-1

Stability Moisture Sensitive
Applications A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.
References Perich, J.W., et al.: Synthesis, 142 (1988)

Formula: C₁₂H₂₈NO₂P

Purity: ~90%

Color and Shape: Neat

Molecular weight: 249.33

Ref: TR-D429300