CAS 117976-89-3

Rabeprazole

Description:

Rabeprazole is a proton pump inhibitor (PPI) commonly used to treat conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers by reducing stomach acid production. It is characterized by its chemical formula, which includes a sulfinyl group, and its structure features a pyridine ring, contributing to its pharmacological activity. Rabeprazole is typically administered in its sodium salt form and is known for its rapid onset of action and relatively long duration of effect. The substance is generally well-absorbed in the gastrointestinal tract, with its bioavailability being influenced by food intake. Rabeprazole is metabolized primarily in the liver through cytochrome P450 enzymes, leading to various metabolites, some of which are pharmacologically active. Its therapeutic effects are often accompanied by a favorable safety profile, although potential side effects may include headache, gastrointestinal disturbances, and, in rare cases, more serious conditions. Overall, rabeprazole is an effective medication for managing acid-related disorders, contributing to improved patient outcomes in gastrointestinal health.

Formula: C₁₈H₂₁N₃O₃S

InChI: InChI=1/C11H16ClNO2/c1-9-10(8-12)13-5-4-11(9)15-7-3-6-14-2/h4-5H,3,6-8H2,1-2H3

InChI key: InChIKey=YREYEVIYCVEVJK-UHFFFAOYSA-N

SMILES: S(CC1=C(C)C(OCCCOC)=CC=N1)(=O)C=2NC=3C(N2)=CC=CC3

Synonyms:

• 117976-89-3
• 1H-Benzimidazole, 2-[[[4-(3-Methoxypropoxy)-3-Methyl-2-Pyridinyl]Methyl]Sulfinyl]-
• 2-(Chloromethyl)-4-(3-Methoxypropoxy)-3-Methylpyridine
• 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
• 2-[4-(3-Methoxy-propoxy)-3-methyl-pyridin-2-ylmethanesulfinyl]-1H-benzoimidazole
• 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methyl]sulfinyl]benzimidazole
• Dexrabeprazol
• Habeprazole
• Ly 307640
• Newprazole
• Pariets
• Pariprazole
• Rabeloc
• Rabemax
• Rabiral
• Rabeprazole
• Rabeprazole Sodium (200 mg) (Sodium 2-[(R)-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl]sulfinyl]benzimidazol-1-ide hydrate)
• 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]-1h-benzoimidazole
• 1H-1,3-benzimidazol-2-yl [4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl sulfoxide-sodium salt
• 2-[(S)-{[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methane}sulfinyl]-1H-1,3-benzodiazole
• y-307640
• 2-[3-Methyl-4-(3-methoxypropoxy)-2-pyridinylmethylsulfinyl]-1H-benzimidazole
• 2-(CHOLROMETHYL)-4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE
• Rebeprazole
• 2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole

Rabeprazole Sodium Salt

CAS: 117976-89-3, 117976-90-6

Formula: C₁₈H₂₀N₃NaO₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 381.43

Ref: 3B-R0115

Rabeprazole

CAS: 117976-89-3

Formula: C₁₈H₂₁N₃O₃S

Molecular weight: 359.44

Ref: ST-EA-CP-R5041

1H-​Benzimidazole, 2-​[[[4-​(3-​methoxypropoxy)​-​3-​methyl-​2-​pyridinyl]​methyl]​sulfinyl]​-

CAS: 117976-89-3

Formula: C₁₈H₂₁N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 359.4426

Ref: IN-DA0081D1

Rabeprazole

CAS: 117976-89-3

Rabeprazole

Purity: ≥95%

Molecular weight: 359.44g/mol

Ref: 54-BUP06414

Rabeprazole

CAS: 117976-89-3

Formula: C₁₈H₂₁N₃O₃S

Molecular weight: 359.44

Ref: 7W-GP0914

Rabeprazole

CAS: 117976-89-3

Formula: C₁₈H₂₁N₃O₃S

Color and Shape: Off-White Solid

Molecular weight: 359.44

Ref: 4Z-R-201

Rabeprazole-d4

CAS: 117976-89-3

Formula: C₁₈H₁₇N₃O₃SD₄

Molecular weight: 363.47

Ref: 4Z-R-202

Rabeprazole

CAS: 117976-89-3

Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells and can be used in the study of gastric ulcers.

Formula: C₁₈H₂₁N₃O₃S

Purity: 97.06%

Color and Shape: White To Yellowish Crystalline Powder

Molecular weight: 359.44

Ref: TM-T19826

Rabeprazole

CAS: 117976-89-3

Rabeprazole is a proton pump inhibitor that suppresses the production of stomach acid by blocking the H+/K+ ATPase enzyme. It is used for the treatment of gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole has been shown to be more effective than omeprazole in reducing gastric acid secretion in two-way crossover studies. Rabeprazole also has been shown to inhibit the growth of antibiotic-resistant strains of bacteria. In addition, rabeprazole binds to metal ions like iron and copper, which may affect its pharmacokinetics and efficacy. This drug is currently being investigated as an analytical method for determination of proton pump inhibitors in human serum and urine samples by electrochemical impedance spectroscopy (EIS).

Formula: C₁₈H₂₁N₃O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 359.44 g/mol

Ref: 3D-IM57864

Rabeprazole

Controlled Product

CAS: 117976-89-3

Stability Hygroscopic
Applications Rabeprazole is a partially reversible gastric proton pump inhibitor.
References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)

Formula: C₁₈H₂₁N₃O₃S

Color and Shape: Neat

Molecular weight: 359.44

Ref: TR-R070540