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CAS 118072-93-8

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Zoledronic acid

Description:
Zoledronic acid is a bisphosphonate compound primarily used in the treatment of osteoporosis and other conditions involving bone metabolism, such as Paget's disease and certain cancers that metastasize to bone. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain or increase bone density. The chemical formula of zoledronic acid is C₇H₁₁N₂O₇P, and it features a phosphonate group, which is crucial for its biological activity. This compound is typically administered intravenously due to its poor oral bioavailability. Zoledronic acid has a high affinity for hydroxyapatite, the mineral component of bone, allowing it to effectively target areas of increased bone turnover. It is generally well-tolerated, although potential side effects can include flu-like symptoms, renal impairment, and, in rare cases, osteonecrosis of the jaw. As a potent inhibitor of bone resorption, zoledronic acid plays a significant role in managing conditions associated with excessive bone loss.
Formula:C5H10N2O7P2
InChI:InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChI key:InChIKey=XRASPMIURGNCCH-UHFFFAOYSA-N
SMILES:C(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O
Synonyms:
  • Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-
  • Phosphonic acid, P,P′-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-
  • P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis[phosphonic acid]
  • (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
  • Zoledronic acid
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