CAS 118362-03-1

5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Description:

The chemical substance known as "5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite," with the CAS number 118362-03-1, is a modified nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at both the 5' and 2' positions to enhance stability and reactivity during synthesis. The presence of the 4,4-Dimethoxytrityl group at the 5' position serves as a protective group, while the tert-butyl dimethylsilyl group at the 2' position provides additional protection against hydrolysis. The cyanoethyl-N,N-diisopropyl phosphoramidite moiety at the 3' position is crucial for the coupling reactions in oligonucleotide synthesis. Overall, this compound is characterized by its stability, reactivity, and utility in the field of molecular biology, particularly in the synthesis of RNA and DNA sequences for research and therapeutic applications.

Formula: C₄₅H₆₁N₄O₉PSi

Synonyms:

• Dmt-2'O-Tbdms-Ru Amidite
• 2'-TBDMS-rU Phosphoramidite
• 5'-O-DMT-2'-TBDMS-rU-3'-CEDPA
• rU Phosphoramidite
• 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-cyanoethyl Phosphoramidite

5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

CAS: 118362-03-1

Formula: C₄₅H₆₁N₄O₉PSi

Purity: 97%

Color and Shape: Solid

Molecular weight: 861.0465

Ref: IN-DA008ZA5

DMT-2’O-TBDMS-rU Phosphorous Amide

CAS: 118362-03-1

DMT-2’O-TBDMS-rU Phosphorous Amide

Purity: 98%

Molecular weight: 861.05g/mol

Ref: 54-OR1013053

2''-O-tert-Butyldimethylsilyl-5''-O-DMT-uridine 3''-CE phosphoramidite

CAS: 118362-03-1

Formula: C₄₅H₆₁N₄O₉PSi

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 861.0

Ref: 7W-GN8370

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite

CAS: 118362-03-1

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite is a nucleoside that is synthesized by the modification of uridine with a 2'-O-tert-butyldimethylsilyl group, followed by coupling with 5'-O-DMT. This nucleoside is used in the synthesis of oligonucleotides for use in gene expression and viral replication studies. It is also used as a building block for the synthesis of other nucleosides. The synthesized product has been shown to be stable and can be stored at room temperature for up to two years without degradation. This product is also compatible with a variety of functionalities, such as acetonitrile and levulinyl.

Formula: C₄₅H₆₁N₄O₉PSi

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 861.04 g/mol

Ref: 3D-PB09445

rU Phosphoramidite

CAS: 118362-03-1

Purity: 97%

Molecular weight: 861.061

Ref: 10-F987878