![5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropy…](https://static.cymitquimica.com/cas-image/thumb-webp/94299-5-o-44-dimethoxytrityl-2-o-tert-butyl-dimethylsilyl-uridine-3-2-cyanoethyl-n-n-diisopropyl-phosphoramidite.webp)
CAS 118362-03-1
:5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
Description:
The chemical substance known as "5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite," with the CAS number 118362-03-1, is a modified nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at both the 5' and 2' positions to enhance stability and reactivity during synthesis. The presence of the 4,4-Dimethoxytrityl group at the 5' position serves as a protective group, while the tert-butyl dimethylsilyl group at the 2' position provides additional protection against hydrolysis. The cyanoethyl-N,N-diisopropyl phosphoramidite moiety at the 3' position is crucial for the coupling reactions in oligonucleotide synthesis. Overall, this compound is characterized by its stability, reactivity, and utility in the field of molecular biology, particularly in the synthesis of RNA and DNA sequences for research and therapeutic applications.
Formula:C45H61N4O9PSi
InChI:InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1
InChI key:SKNLXHRBXYGJOC-ZMHKPELYSA-N
SMILES:CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
Synonyms:- Dmt-2'O-Tbdms-Ru Amidite
- 2'-TBDMS-rU Phosphoramidite
- 5'-O-DMT-2'-TBDMS-rU-3'-CEDPA
- rU Phosphoramidite
- 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-cyanoethyl Phosphoramidite
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U β-Cyanoethyl Phosphoramidite
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C45H61N4O9PSiColor and Shape:White PowderMolecular weight:860.39454DMT-2'O-TBDMS-rU Phosphorous Amide
CAS:DMT-2'O-TBDMS-rU Phosphorous AmideFormula:C45H61N4O9PSiPurity:98%Molecular weight:861.052''-O-tert-Butyldimethylsilyl-5''-O-DMT-uridine 3''-CE phosphoramidite
CAS:Formula:C45H61N4O9PSiPurity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:861.0(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS:Formula:C45H61N4O9PSiPurity:97%Color and Shape:SolidMolecular weight:861.04652'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite
CAS:2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite is a nucleoside that is synthesized by the modification of uridine with a 2'-O-tert-butyldimethylsilyl group, followed by coupling with 5'-O-DMT. This nucleoside is used in the synthesis of oligonucleotides for use in gene expression and viral replication studies. It is also used as a building block for the synthesis of other nucleosides. The synthesized product has been shown to be stable and can be stored at room temperature for up to two years without degradation. This product is also compatible with a variety of functionalities, such as acetonitrile and levulinyl.
Formula:C45H61N4O9PSiPurity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:861.04 g/molDMT-2′O-TBDMS-rU Phosphoramidite
CAS:(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramiditeFormula:C45H61N4O9PSiPurity:97%Molecular weight:861.052'-O-TBDMS-U-3'-CE-phosphoramidite
CAS:2'-O-TBDMS-U-3'-CE-phosphoramidite can be used in research related to oligonucleotide synthesis.Formula:C45H61N4O9PSiMolecular weight:861.062'-O-TBDMS-U-3'-CE-phosphoramidite
CAS:2'-O-TBDMS-U-3'-CE-phosphoramidite can be used in research related to oligonucleotide synthesis.Formula:C45H61N4O9PSiMolecular weight:861.06
