CAS 118409-62-4

tyrphostin ag 126

Description:

Tyrphostin AG 126 is a synthetic compound known for its role as a selective inhibitor of receptor tyrosine kinases, particularly the epidermal growth factor receptor (EGFR). It is classified as a small molecule and is often utilized in biochemical research to study signal transduction pathways and cellular processes influenced by tyrosine phosphorylation. The compound exhibits characteristics typical of tyrosine kinase inhibitors, including the ability to interfere with cell proliferation and survival in various cancer cell lines. Tyrphostin AG 126 is typically characterized by its moderate solubility in organic solvents and limited solubility in water, which can affect its bioavailability in experimental settings. Its chemical structure features a phenyl group and a substituted imidazole, contributing to its binding affinity for target kinases. Researchers often employ this compound in studies related to cancer biology, drug development, and the exploration of therapeutic strategies targeting tyrosine kinase-mediated signaling pathways. As with many chemical substances, safety precautions should be observed when handling Tyrphostin AG 126 in laboratory environments.

Formula: C₁₀H₅N₃O₃

InChI: InChI=1/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H

SMILES: c1cc(c(cc1C=C(C#N)C#N)O)N(=O)=O

Synonyms:

• Ag 126
• (3-Hydroxy-4-Nitrobenzylidene)Propanedinitrile

Propanedinitrile,2-[(3-hydroxy-4-nitrophenyl)methylene]-

CAS: 118409-62-4

Formula: C₁₀H₅N₃O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 215.1650

Ref: IN-DA007QB4

AG126

CAS: 118409-62-4

AG126

Purity: ≥95%

Molecular weight: 215.16g/mol

Ref: 54-BUP10228

AG-126

CAS: 118409-62-4

Formula: C₁₀H₅N₃O₃

Purity: >98.0%(GC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 215.17

Ref: 3B-A3345

AG-126

CAS: 118409-62-4

AG-126

Formula: C₁₀H₅N₃O₃

Purity: 99.3% (Typical Value in Batch COA)

Color and Shape: yellow solid

Molecular weight: 215.17g/mol

Ref: 54-BISN0202

AG126

CAS: 118409-62-4

AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.

Formula: C₁₀H₅N₃O₃

Purity: 97.35%

Color and Shape: Solid

Molecular weight: 215.16

Ref: TM-T4092

AG 126

CAS: 118409-62-4

AG 126 is a nanoparticulate composition with the ability to inhibit LPS-induced inflammatory response in vitro. In vivo, AG 126 reduces the severity of eye disorders and bowel disease, as well as an infectious disease caused by BCR-ABL kinase. This drug also has a positive effect on pluripotent cells, which have been shown to be useful for regenerative medicine. AG 126 has been shown to inhibit the activity of toll-like receptor 4 (TLR4), which is a membrane protein that responds to bacterial and viral components. The kinetic energy of AG 126 particles can trigger apoptosis in infected cells through mitochondrial membrane potential collapse and induction of reactive oxygen species.

Formula: C₁₀H₅N₃O₃

Purity: Min. 95%

Molecular weight: 215.17 g/mol

Ref: 3D-TEA40962