CAS 118457-14-0: Nebivolol

Description: Nebivolol is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure by reducing heart rate and myocardial contractility, thereby decreasing cardiac output. Nebivolol is unique among beta-blockers due to its vasodilatory properties, which are attributed to its ability to stimulate the release of nitric oxide, leading to improved endothelial function. The substance is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Nebivolol is generally well-tolerated, with a side effect profile that may include fatigue, headache, and dizziness, though it is less likely to cause bronchoconstriction compared to non-selective beta-blockers. Its chemical structure includes a chiral center, resulting in different enantiomers that contribute to its pharmacological effects. Overall, Nebivolol represents a modern approach to managing cardiovascular conditions with a focus on efficacy and safety.

Formula: C₂₂H₂₅F₂NO₄

InChI: InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/s2

InChI key: InChIKey=KOHIRBRYDXPAMZ-BAICYHKCNA-N

SMILES: FC1=CC=C2OC(CCC2=C1)C(O)CNCC(O)C3OC4=CC=C(F)C=C4CC3

Synonyms:

• (iminobis(methylene))bis(6-fluoro-3,4-dihydro-
• (±)-[2R*(1S*5S*(S*))]-α,α′-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
• 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]
• 2H-1-Benzopyran-2-methanol, alpha,alpha'-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, [2R*[R*[R*(S*)]]]-
• 2H-1-benzopyran-2-methanol)
• Bystolic
• Nebivolol-D4
• Nibivolol
• Nobiten
• R 065824
• Vasoxen
• [2R*[R*[R*(S*)]]]-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
• alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-
• dl-Nebivolol
• rel-(αR,α′R,2R,2′S)-α,α′-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-
• 2H-1-benzopyran-2-methanol)
• 2H-1-Benzopyran-2-methanol, alpha,alpha'-
• (iminobis(methylene))bis(6-fluoro-3,4-dihydro-
• (±)-Nebivolol

Nebivolol Hydrochloride

CAS: 118457-14-0152520-56-4

• Formula: C₂₂H₂₅F₂NO₄·HCl
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 441.90

Nebivolol

CAS: 118457-14-0

β1-selective adrenergic receptor antagonist

• Formula: C₂₂H₂₅F₂NO₄
• Purity: Min. 95%
• Molecular weight: 405.44 g/mol