CAS 152520-56-4

Nebivolol hydrochloride

Description:

Nebivolol hydrochloride is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure by reducing heart rate and myocardial contractility, thereby decreasing cardiac output. Nebivolol is unique among beta-blockers due to its vasodilatory properties, which are attributed to its ability to stimulate the release of nitric oxide, leading to improved endothelial function. The substance is typically administered orally and is well-absorbed, with a favorable pharmacokinetic profile that includes a long half-life, allowing for once-daily dosing. Nebivolol hydrochloride is generally well-tolerated, with a side effect profile that may include headache, fatigue, and gastrointestinal disturbances. Its chemical structure includes a chiral center, resulting in different pharmacological effects between its enantiomers. Overall, Nebivolol hydrochloride represents a modern approach to managing cardiovascular conditions, combining efficacy with a relatively favorable safety profile.

Formula: C₂₂H₂₅F₂NO₄·ClH

InChI: InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/s2

InChI key: InChIKey=JWEXHQAEWHKGCW-NJEBDULONA-N

SMILES: [C@@H](CNC[C@H](O)[C@]1(OC=2C(CC1)=CC(F)=CC2)[H])(O)[C@@]3(OC=4C(CC3)=CC(F)=CC4)[H].Cl

Synonyms:

• 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-
• Lobivon
• Nebicard
• Nebilet
• Nebilox
• Nebivolol hcl
• Nebivololhydrochloride(Subjecttopatentfree)
• Nodon
• R 067555
• R-67555
• Rac Nebivolol, Hydrochloride
• a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
• NEBIVOLOL HC
• Nebivolol (Bystolic)
• alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• D06622
• a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• Nebivolol hydrochloride (usan)
• Nebivolol hydrochloride, >=98%
• (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
• rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
• Nebivolol hydrochloride
• Bystolic
• Narbivolol

Nebivolol Hydrochloride

CAS: 152520-56-4

Color and Shape: Neat

Ref: 61-FOR0947.00

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

CAS: 152520-56-4

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002306

NEBIVOLOL HYDROCHLORIDE CRS

CAS: 152520-56-4

NEBIVOLOL HYDROCHLORIDE CRS

Color and Shape: Added

Ref: 41-Y0002299

Nebivolol Hydrochloride

CAS: 152520-56-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₂H₂₅F₂NO₄·HCl

Color and Shape: White Off-White Powder

Molecular weight: 441.15184

Ref: 45-1457833

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.

Formula: C₂₂H₂₅F₂NO₄·HCl

Purity: 99.77% - >99.99%

Color and Shape: White Solid

Molecular weight: 441.90

Ref: TM-T0154

Nebivolol Hydrochloride

CAS: 152520-56-4

Nebivolol Hydrochloride

Formula: C₂₂H₂₆ClF₂NO₄

Purity: 98%

Molecular weight: 441.9

Ref: 54-PC108965

Nebivolol Hydrochloride

CAS: 152520-56-4

Formula: C₂₂H₂₆ClF₂NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 441.8959

Ref: IN-DA007YL0

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride

Formula: C₂₂H₂₅F₂NO₄·HCl

Purity: ≥98%, 10 mM in DMSO

Molecular weight: 441.9

Ref: 54-BUP15662

Nebivolol hydrochloride

CAS: 152520-56-4

Formula: C₂₂H₂₅F₂NO₄·HCl

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 441.90

Ref: 7W-GP6004

Nebivolol HCl

CAS: 152520-56-4

Formula: C₂₂H₂₅F₂NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 405.45 36.46

Ref: 4Z-N-201

Nebivolol Hydrochloride

Controlled Product

CAS: 152520-56-4

Formula: C₂₂H₂₅F₂NO₄·ClH

Color and Shape: Neat

Molecular weight: 441.90

Ref: 86-MM0947.00

Nebivolol hydrochloride (Standard)

CAS: 152520-56-4

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Formula: C₂₂H₂₅F₂NO₄·HCl

Molecular weight: 441.90

Ref: TM-TMSM-1712

Nebivolol Hydrochloride

CAS: 152520-56-4

Formula: C₂₂H₂₅F₂NO₄HCl

Molecular weight: 405.4 : 36.46

Ref: ST-EA-CP-N5020

Nebivolol Hydrochloride

CAS: 152520-56-4

Applications Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.
References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990);

Formula: C₂₂H₂₅F₂NO₄·ClH

Color and Shape: Neat

Molecular weight: 441.9

Ref: TR-N387935

Nebivolol hydrochloride

Controlled Product

CAS: 152520-56-4

Nebivolol HCl is a beta-blocker that is used to treat high blood pressure and heart failure. It is a prodrug that is metabolized in vivo to its active form, nebivolol. Nebivolol HCl has a low bioavailability of about 5%, which may be due to the presence of excipients or the formation of solid dispersions with other ingredients in the formulation. Nebivolol HCl also interacts with many drugs that are metabolized by CYP2D6, CYP3A4, and CYP1A2 enzymes, such as metoprolol succinate, sodium citrate, and hydrochloric acid. This drug also has an adverse effect on geriatric patients because it can cause dizziness due to orthostatic hypotension.

Formula: C₂₂H₂₅F₂NO₄•HCl

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 441.9 g/mol

Ref: 3D-FN36779

Nebivolol HCl - Bio-X ™

Controlled Product

CAS: 152520-56-4

Nebivolol is a beta-blocker that is used to treat high blood pressure. It is also used in the treatment of angina, to decrease the heart rate and contractile force. Nebivolol has weak beta-2 adrenergic receptor antagonist action but is a highly selective beta-1 adrenergic receptor antagonist. Nebivolol's ability to block beta-1 adrenergic receptors results in a reduction in myocardial contractility, systolic and diastolic blood pressure, resting heart rate, and workout heart rate.

Formula: C₂₂H₂₅F₂NO₄·HCl

Purity: (%) Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 441.9 g/mol

Ref: 3D-BN164638

Nebivolol Hydrochloride

CAS: 118457-14-0, 152520-56-4

Formula: C₂₂H₂₅F₂NO₄·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 441.90

Ref: 3B-N0954

Nebivolol hydrochloride

CAS: 152520-56-4

Formula: C₂₂H₂₅F₂NO₄·ClH

Color and Shape: Neat

Molecular weight: 441.90

Ref: 04-C15499900