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CAS 1185255-99-5

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2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil

Description:
2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil is a chemical compound that belongs to the class of angiotensin II receptor antagonists, which are primarily used in the treatment of hypertension and heart failure. This compound is a derivative of candesartan cilexetil, characterized by the removal of an ethoxy group and the introduction of a hydroxy group, which may influence its pharmacological properties. It typically exhibits high affinity for the angiotensin II receptor, leading to vasodilation and reduced blood pressure. The molecular structure includes a biphenyl moiety, which is common in many antihypertensive agents, contributing to its biological activity. The compound is usually administered in a prodrug form, which is converted into its active form in the body. Its solubility, stability, and bioavailability are critical factors that determine its effectiveness as a therapeutic agent. As with many pharmaceuticals, safety and efficacy profiles are established through clinical studies, and potential side effects may include dizziness, fatigue, or gastrointestinal disturbances.
Formula:C33H34N6O6
InChI:InChI=1S/C33H34N6O6/c1-3-39-30(35-36-37-39)26-13-8-7-12-25(26)23-18-16-22(17-19-23)20-38-29-27(14-9-15-28(29)34-32(38)41)31(40)43-21(2)44-33(42)45-24-10-5-4-6-11-24/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,34,41)
InChI key:DEGBAMTUFHKMQR-UHFFFAOYSA-N
SMILES:CCN1C(=NN=N1)C2=CC=CC=C2C3=CC=C(C=C3)CN4C5=C(C=CC=C5NC4=O)C(=O)OC(C)OC(=O)OC6CCCCC6
Synonyms:
  • Candygram
  • 3-[[2'-(1-Ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylic acid 2-oxo-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Found 6 products.