CAS 1187431-43-1
:Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1′-sulfinylbis[methane] (1:1)
Description:
Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1′-sulfinylbis[methane] (1:1) is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups and a bicyclic framework. The presence of acetamide suggests potential for hydrogen bonding, influencing its solubility and reactivity. The compound features a cyclopropyl group, which may impart unique steric and electronic properties, while the fluoro and iodo substituents on the phenyl ring can enhance its biological activity and lipophilicity. The trioxopyrido[4,3-d]pyrimidine moiety indicates potential pharmacological relevance, possibly as a bioactive agent. The sulfinylbis[methane] component suggests the formation of a stable adduct, which may affect the compound's stability and interaction with biological targets. Overall, this compound's characteristics make it a subject of interest in medicinal chemistry and drug development, although specific properties such as melting point, boiling point, and solubility would require empirical determination.
Formula:C26H23FIN5O4·C2H6OS
InChI:InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3
InChI key:InChIKey=OQUFJVRYDFIQBW-UHFFFAOYSA-N
SMILES:N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5.S(C)(C)=O
Synonyms:- Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1′-sulfinylbis[methane] (1:1)
- Gsk 1120212B
- Trametinib DMSO
- Trametinib dimethyl sulfoxide
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Found 9 products.
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2h)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)
CAS:Formula:C28H29FIN5O5SPurity:98%Color and Shape:SolidMolecular weight:693.5282Trametinib (DMSO solvate)
CAS:<p>Trametinib (DMSO solvate)</p>Purity:≥98%Molecular weight:693.53g/molTrametinib Dimethyl Sulfoxide
CAS:Formula:C26H23FIN5O4·C2H6OSColor and Shape:Off-White SolidMolecular weight:615.40 78.13Trametinib
CAS:Formula:C26H23FIN5O4Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white solid powderMolecular weight:615.39Trametinib (DMSO solvate)
CAS:<p>Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)</p>Formula:C28H29FIN5O5SPurity:98.82% - 99.92%Color and Shape:SolidMolecular weight:693.53Trametinib (DMSO Solvate)
CAS:<p>Applications Trametinib (DMSO Solvate) is a highly potent and selective MEK inhibitor with significant antitumor activity.<br>References Abe, H., et al.: ACS Med. Chem. Lett., 2, 320 (2011)<br></p>Formula:C26H23FIN5O4·C2H6OSColor and Shape:NeatMolecular weight:693.53GSK 1120212B
CAS:<p>Inhibits MEK1 and MEK2 kinases; targeted therapy for melanoma</p>Formula:C26H23FIN5O4•C2H6OSPurity:Min. 95%Color and Shape:PowderMolecular weight:693.53 g/mol
