CAS 119410-08-1
:3-HYDROXY DESLORATADINE HCL
Description:
3-Hydroxy Desloratadine HCl is a derivative of desloratadine, which is an antihistamine commonly used to treat allergic symptoms such as rhinitis and urticaria. This compound is characterized by its ability to selectively antagonize peripheral H1 receptors, thereby reducing the effects of histamine in the body. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range suitable for pharmaceutical formulations. The presence of the hydroxyl group in its structure enhances its pharmacological properties, potentially improving its efficacy and safety profile compared to its parent compound. As a hydrochloride salt, it is typically more stable and easier to handle in a pharmaceutical context. The compound is generally well-tolerated, with a side effect profile similar to that of other second-generation antihistamines, including drowsiness in some individuals. Its therapeutic applications primarily focus on alleviating allergic reactions, making it a valuable option in allergy management.
Formula:C19H19ClN2O
InChI:InChI=1/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
SMILES:C1Cc2cc(cnc2C(=C2CCNCC2)c2ccc(cc12)Cl)O
Synonyms:- 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
- Sch 45581
- 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
- 3-Hydroxydesloratadine
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Found 9 products.
3-Hydroxy Desloratadine (8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol)
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C19H19ClN2OColor and Shape:Pale Brown SolidMolecular weight:326.118595H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-3-OL, 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDINYLIDENE)-
CAS:Formula:C19H19ClN2OPurity:95%Color and Shape:SolidMolecular weight:326.82008-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
CAS:8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-olPurity:95%Molecular weight:326.83g/mol3-Hydroxy Desloratadine
CAS:Formula:C19H19ClN2OColor and Shape:Pale Brown SolidMolecular weight:326.823-hydroxy Desloratidine
CAS:3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.Formula:C19H19ClN2OColor and Shape:SolidMolecular weight:326.823-Hydroxy Desloratadine
CAS:Controlled ProductFormula:C19H19ClN2OColor and Shape:NeatMolecular weight:326.823-Hydroxy Desloratadine Dihydrochloride
CAS:Controlled ProductFormula:C19H19ClN2O·2(HCl)Color and Shape:NeatMolecular weight:363.283-Hydroxy desloratadine
CAS:<p>3-Hydroxy desloratadine is a metabolite of desloratadine. It is one of the metabolites that can be formed from the drug in vivo, after oral administration. 3-Hydroxy desloratadine has been shown to be an active metabolite in vitro and in vivo, with linear calibration curves (R2>0.99) for both human liver and human plasma samples. The metabolic profile of 3-hydroxy desloratadine is similar to that of desloratadine, including inhibition of cytochrome P450 enzymes and glucuronidation by glucuronidases. In vitro studies have shown that 3-hydroxy desloratadine is not a substrate for CYP2D6 or CYP3A4, but it may inhibit CYP1A2 and CYP2C19. It has also been shown to be a substrate for UGT1A6 and UGT2B7.</p>Formula:C19H19ClN2OPurity:Min. 95%Molecular weight:326.82 g/mol
![5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-3-OL, 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDINYLIDENE)-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000IR2.jpg&w=3840&q=75)
