CAS 119413-54-6

Topotecan hydrochloride

Description:

Topotecan hydrochloride is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, including ovarian cancer and small cell lung cancer. It is a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication, ultimately leading to cell death. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Its molecular formula includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. Topotecan hydrochloride is typically administered in a clinical setting under strict medical supervision due to potential side effects, which can include nausea, vomiting, and myelosuppression. The drug's mechanism of action involves the stabilization of the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands and thereby disrupting the cell cycle. As with many chemotherapeutic agents, its use is carefully monitored to balance efficacy with the risk of adverse effects.

Formula: C₂₃H₂₃N₃O₅·ClH

InChI: InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChI key: InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N

SMILES: C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=C(O)C5CN(C)C)COC1=O.Cl

Synonyms:

• SKF 104864A
• Topotecan HCl
• (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
• Hycamtin
• (S)-10-((Dimethylamino)Methyl)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride
• Nogitecan hydrochloride
• (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• NSC 609669
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-
• (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride (1:1)

Topotecan Hydrocholoride

CAS: 119413-54-6

Formula: C₂₃H₂₃N₃O₅·HCl

Purity: >95.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 457.91

Ref: 3B-T2795

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride

CAS: 119413-54-6

Formula: C₂₃H₂₄ClN₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 457.9068

Ref: IN-DA0039LU

Topotecan hydrochloride

CAS: 119413-54-6

Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.

Formula: C₂₃H₂₄ClN₃O₅

Purity: 97.88% - 99.41%

Color and Shape: White Crystalline Solid

Molecular weight: 457.92

Ref: TM-T1174

Topotecan hydrochloride

CAS: 119413-54-6

Topotecan hydrochloride

Purity: ≥95%

Molecular weight: 457.92g/mol

Ref: 54-BUP13571

Topotecan hydrochloride

CAS: 119413-54-6

Formula: C₂₃H₂₄ClN₃O₅

Purity: (HPLC) ≥ 99.0%

Color and Shape: Light-yellow to yellow crystalline powder

Molecular weight: 457.91

Ref: 7W-GP8771

Topotecan HCl

CAS: 119413-54-6

Formula: C₂₃H₂₃N₃O₅·HCl

Color and Shape: Yellow Solid

Molecular weight: 421.45 36.46

Ref: 4Z-T-264

Topotecan Hydrochloride

CAS: 119413-54-6

Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride.

Formula: C₂₃H₂₄ClN₃O₅

Purity: 95%~99%

Molecular weight: 457.911

Ref: BP-BP1399

Topotecan Hydrochloride

CAS: 119413-54-6

Color and Shape: Neat

Ref: 86-MM1330.00

Topotecan Hydrochloride Salt

CAS: 119413-54-6

Topotecan Hydrochloride Salt

Purity: 99%

Molecular weight: 457.91g/mol

Ref: 54-BIFK0005

Topotecan Hydrochloride

CAS: 119413-54-6

Applications A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990), BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991), Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992),

Formula: C₂₃H₂₃N₃O₅·ClH

Color and Shape: Light Yellow To Dark Green

Molecular weight: 457.91

Ref: TR-T542500

Topotecan hydrochloride

CAS: 119413-54-6

Inhibitor of TOP1 topoisomerase; anti-cancer

Formula: C₂₃H₂₃N₃O₅•HCl

Color and Shape: Powder

Molecular weight: 457.91 g/mol

Ref: 3D-FT28329

Topotecan USP Related Compound A

Controlled Product

CAS: 119413-54-6

Applications Topotecan USP Related Compound A is one of the Topotecn (T542500) impurities, similar to (S)-(+)-Camptothecin (C175150).

Formula: C₂₄H₂₅N₃O₆

Color and Shape: Neat

Molecular weight: 456.104

Ref: TR-T542515