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Topotecan hydrochloride

CAS 119413-54-6: Topotecan hydrochloride

Description:Topotecan hydrochloride is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, including ovarian cancer and small cell lung cancer. It is a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication, ultimately leading to cell death. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Its molecular formula includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. Topotecan hydrochloride is typically administered in a clinical setting under strict medical supervision due to potential side effects, which can include nausea, vomiting, and myelosuppression. The drug's mechanism of action involves the stabilization of the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands and thereby disrupting the cell cycle. As with many chemotherapeutic agents, its use is carefully monitored to balance efficacy with the risk of adverse effects.

Formula:C23H23N3O5·ClH

InChI:InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChI key:InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N

SMILES:Cl.O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC(O)=C(C5=CC4C3)CN(C)C

  • Synonyms:
  • SKF 104864A
  • Topotecan HCl
  • (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
  • Hycamtin
  • (S)-10-((Dimethylamino)Methyl)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride
  • Nogitecan hydrochloride
  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • NSC 609669
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-
  • See more synonyms
  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride (1:1)
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-
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Found 11 products.

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Topotecan Hydrocholoride

CAS:119413-54-6

Ref: 3B-T2795

250mg106.00 €
Estimated delivery in United States, on Tuesday 25 Feb 2025
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Topotecan hydrochloride

CAS:119413-54-6

Ref: TM-T1174

1g512.00 €
5mg35.00 €
10mg51.00 €
25mg80.00 €
50mg107.00 €
100mg144.00 €
500mg344.00 €
1mL*10mM (DMSO)55.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Topotecan HCl

CAS:119413-54-6

Ref: 4Z-T-264

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Monday 3 Mar 2025
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Topotecan hydrochloride

CAS:119413-54-6

Ref: 7W-GP8771

100mg148.00 €
Estimated delivery in United States, on Monday 3 Mar 2025
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Topotecan Hydrochloride

CAS:119413-54-6

Ref: 86-MM1330.00-0250

250mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Topotecan Hydrochloride

CAS:119413-54-6

Ref: BP-BP1399

20mg53.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Topotecan Hydrochloride Salt

CAS:119413-54-6

Ref: 54-BIFK0005

1g163.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Topotecan Hydrochloride

CAS:119413-54-6

Ref: TR-T542500

1g408.00 €
50mg151.00 €
100mg235.00 €
Estimated delivery in United States, on Wednesday 12 Mar 2025
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Topotecan hydrochloride

CAS:119413-54-6

Ref: 3D-FT28329

1g1,063.00 €
50mg278.00 €
100mg418.00 €
250mg558.00 €
500mg744.00 €
Estimated delivery in United States, on Thursday 13 Mar 2025
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Topotecan USP Related Compound A

Controlled Product
CAS:119413-54-6

Ref: TR-T542515

50mg32,646.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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