CAS 119413-54-6
:Topotecan hydrochloride
Description:
Topotecan hydrochloride is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, including ovarian cancer and small cell lung cancer. It is a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication, ultimately leading to cell death. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Its molecular formula includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. Topotecan hydrochloride is typically administered in a clinical setting under strict medical supervision due to potential side effects, which can include nausea, vomiting, and myelosuppression. The drug's mechanism of action involves the stabilization of the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands and thereby disrupting the cell cycle. As with many chemotherapeutic agents, its use is carefully monitored to balance efficacy with the risk of adverse effects.
Formula:C23H23N3O5·ClH
InChI:InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChI key:InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N
SMILES:C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=C(O)C5CN(C)C)COC1=O.Cl
Synonyms:- SKF 104864A
- Topotecan HCl
- (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
- Hycamtin
- (S)-10-((Dimethylamino)Methyl)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride
- Nogitecan hydrochloride
- (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- NSC 609669
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-
- (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride (1:1)
- See more synonyms
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Topotecan Hydrochloride
CAS:Formula:C23H23N3O5·HClPurity:>95.0%(HPLC)(T)Color and Shape:Light yellow to Yellow powder to crystalMolecular weight:457.91Topotecan hydrochloride
CAS:Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Formula:C23H24ClN3O5Purity:97.88% - 99.41%Color and Shape:SolidMolecular weight:457.92Topotecan hydrochloride
CAS:Topotecan hydrochlorideFormula:C23H24ClN3O5Purity:≥95%Molecular weight:457.92(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
CAS:Formula:C23H24ClN3O5Purity:98%Color and Shape:SolidMolecular weight:457.9068Topotecan Hydrochloride
CAS:Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride.Formula:C23H24ClN3O5Purity:95%~99%Molecular weight:457.911Topotecan Hydrochloride
CAS:Applications A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990), BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991), Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992),Formula:C23H23N3O5·ClHColor and Shape:NeatMolecular weight:457.91Topotecan Hydrochloride Salt
CAS:Topotecan Hydrochloride SaltFormula:C23H23N3O5·ClHPurity:99%Color and Shape:SolidMolecular weight:457.90675Topotecan HCl
CAS:(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochlorideFormula:C23H24ClN3O5Purity:98%Molecular weight:457.91Topotecan hydrochloride
CAS:Formula:C23H24ClN3O5Purity:(HPLC) ≥ 99.0%Color and Shape:Light-yellow to yellow crystalline powderMolecular weight:457.91Topotecan hydrochloride
CAS:Inhibitor of TOP1 topoisomerase; anti-cancerFormula:C23H23N3O5•HClColor and Shape:PowderMolecular weight:457.91 g/molTopotecan USP Related Compound A
CAS:Controlled ProductApplications Topotecan USP Related Compound A is one of the Topotecn (T542500) impurities, similar to (S)-(+)-Camptothecin (C175150).
Formula:C24H25N3O6Color and Shape:NeatMolecular weight:456.104
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